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Effects of Substance P on Blood Flow of the Dental Pulp in Dogs

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Substance P and Neurokinins

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Abstract

Substance P (SP) is a known potent vasodilator (1, 2, 3). Olgart and his coworkers found SP-like immunoreactivity (SPLI) in nerves of the cat pulp suggesting the presence of SP (4). In addition, Gazelius and Olgart (5) demonstrated that electrical stimulation of the inferior alveolar nerve in cats caused a rapid increase in pulp blood flow which was followed by a prolonged reduction in pulp blood flow. The increase is thought to be mediated by SP released at the pulpal sensory nerve endings (6). However, administration of synthetic SP failed to increase pulp blood flow in cats; only when the vascular tone was elevated by electrical stimulation of the sympathetic nerve did the SP administration cause a pulp blood flow increase (5).

Supp. by NIH Grants DE00505 and DE00121.

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References

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Authors and Affiliations

  1. Lab. of Oral Physiology and Department of Endodontics, Columbia University, School of Dental and Oral Surgery, 630 W 168th Street, New York, NY, 10032, USA

    S. Kim & J. Dorscher-Kim

Authors
  1. S. Kim
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  2. J. Dorscher-Kim
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Editor information

Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    James L. Henry Ph.D.

  2. Department of Physiology, University of Montreal, C.P. 6208, Montreal, Quebec, H3C 3T8, Canada

    Rejean Couture Ph.D.

  3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    A. Claudio Cuello M.D.

  4. MRC Group in Molecular Endocrinology, Centre Hospitalier de L’Universite, Laval, Quebec, G1V 4G2, Canada

    Georges Pelletier Ph.D.

  5. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Verdun, Quebec, H4H 1R3, Canada

    Remi Quirion Ph.D.

  6. Department of Pharmacology, Medical School, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada

    Domenico Regoli M.D.

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© 1987 Springer-Verlag New York Inc.

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Kim, S., Dorscher-Kim, J. (1987). Effects of Substance P on Blood Flow of the Dental Pulp in Dogs. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_65

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  • DOI: https://doi.org/10.1007/978-1-4612-4672-5_65

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9109-1

  • Online ISBN: 978-1-4612-4672-5

  • eBook Packages: Springer Book Archive

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