Abstract
The differentiation of round spermatids to spermatozoa is accompanied by extensive changes in gene expression. A distinct set of genes is exclusively transcribed in round spermatids at high levels and encodes a number of chromosomal proteins involved in nuclear condensation, a set of proteins involved in acrosome formation and formation of sperm tails, and testis-specific isoforms of various enzymes. The switch in gene expression that accompanies the transition from spermatocytes to spermatids results mainly from changes in transcription (1), although RNA processing (2) and translational control (3) are also implicated in some instances. Evidence for the importance of transcriptional control comes from transgenic mouse experiments, which show that a number of spermatid-specific promoters (mP1, mP2, tACE, RT7) confer correct spatial and temporal expression onto reporter genes (4–7). Examination of promoter sequences suggest that various small sequences are conserved among spermatid-specific promoters (8). One of these resembles the adenosine 3′:5′-cyclic monophosphate (cAMP) response element (CRE) and is found in approximately the same relative position in these promoters (9). CRE elements interact with members of the CREB and CREM families of transcription factors.
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Oosterhuis, J.H., Van Der Hoorn, F.A. (1996). CREMτ Activates the Spermatid-Specific RT7 and Mouse Protamine 1 Promoters. In: Desjardins, C. (eds) Cellular and Molecular Regulation of Testicular Cells. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2374-0_6
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DOI: https://doi.org/10.1007/978-1-4612-2374-0_6
Publisher Name: Springer, New York, NY
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