Abstract
Various cytotoxic agents, including radiation and several chemotherapeutic drugs, produce prolonged depression of spermatogenesis in rodents and humans (1–3). However, pretreatment of rats with hormones that suppress intratesticular levels of testosterone and the completion of spermatogenesis enhances the recovery of spermatogenesis from stem cells after the cytotoxic insult (4). Although most studies of hormonal protection have employed the chemotherapeutic drug procarbazine as the cytotoxic agent, protection has also been shown following cyclophosphamide (5) and gamma irradiation (6). It had generally been assumed that the protection of spermatogenic function was a result of protecting the stem spermatogonia against killing, although alternative mechanisms such as enhancement of the number of stem cells at the time of cytotoxic treatment or of their recovery following such treatments have also been suggested (7–9).
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Meistrich, M.L., Wilson, G., Kangasniemi, M. (1998). Hormonal Protection of Spermatogenic Stem Cells Against Cytotoxic Agents. In: Zirkin, B.R. (eds) Germ Cell Development, Division, Disruption and Death. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2206-4_19
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DOI: https://doi.org/10.1007/978-1-4612-2206-4_19
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