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The Testis pp 10–18Cite as

Spermatogenesis After the Millennium

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Abstract

As predicted for the Macintosh computer, spermatogenesis will continue after Y2K. In fact, continued overpopulation and high levels of infertility, as well as discoveries such as Viagra, lend great importance to improved understanding of the mechanisms that regulate male reproduction. In this chapter, I will discuss a few areas of research that should be vigorously pursued in the coming years. The topics to be discussed are restricted to the testis, and represent only a limited vision for future research in andrology as seen by one with the bias of a molecular biologist.

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References

  1. .Dym M. Spermatogonial stem cells of the testis. Proc Natl Acad Sci USA 1994;91:11287–89.

    Article  PubMed  CAS  Google Scholar 

  2. Dym M, Clermont Y. Role of spermatogonia in the repair of the seminiferous epithelium following x-irradiation of the rat testis. Am J Anat 1970;128:265–82.

    Article  PubMed  CAS  Google Scholar 

  3. Huckins C. The spermatogonial stem cell population in rats. Anat Rec 1971;169:533–58.

    Article  PubMed  CAS  Google Scholar 

  4. Oakberg EF. Spermatogonial stem cell renewal in the mouse. Am J Anat 1971;169:515–32.

    CAS  Google Scholar 

  5. Beck A, Miller I, Anderson P, Streuli M. RNA-binding protein, TIAR, is essential for primordial germ cell development. Proc Natl Acad Sci USA 1998;95:2331–36.

    Article  PubMed  CAS  Google Scholar 

  6. Beamer WG, Cunliffe-Beamer TL, Shultz KL, Langley SH, Roderick TH. Juvenile spermatogonial depletion (jsd): a genetic defect of germ cell proliferation of male mice. Biol Reprod 1988;38:899–908.

    Article  PubMed  CAS  Google Scholar 

  7. Eddy EM, O’Brien DA. Gene expression during mammalian meiosis. Curr Top Dev Biol 1997;37:141–200.

    Article  Google Scholar 

  8. Dix DJ, Allen JW, Collins BW, Mori C, Nakamura N, Poorman—Allen P, et al. Targeted gene disruption of Hsp-70-2results in failed meiosis, germ cell apoptosis, and male infertility. Proc Natl Acad Sci USA 1996;93:3264–68.

    Article  PubMed  CAS  Google Scholar 

  9. Zhu, D, Dix DJ, Eddy, EM. HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes. Development 1997;124:3007–14.

    PubMed  CAS  Google Scholar 

  10. Liu D, Matzuk M, Sung WK, Guo Q, Wang P, Wolgemuth D. Cyclin Al is required for meiosis in the male mouse. Nat Genet 1988;20:377–80.

    Google Scholar 

  11. Chu S, DeRisi J, Eisen M, Mulholland J, Botstein D, Brown P, et al. The transcriptional program of sporulation in budding yeast. Science 1998;282:699–705.

    Article  PubMed  CAS  Google Scholar 

  12. Hecht NB. Molecular mechanism of male germ cell differentiation. BioEssays 1998;20:555–61.

    Article  PubMed  CAS  Google Scholar 

  13. Sertoli E. Dell’esistenza di particolari cellule ramificate nei canalicoli seminiferi del testicolo umano. Morgagni 1865;7:31–40.

    Google Scholar 

  14. Calderwood, KA, Handel MA. Protamine transcript sharing among postmeiotic spermatids. Proc Natl Acad Sci USA 1991;88:2407–11.

    Article  Google Scholar 

  15. Griswold MD. Interactions between Sertoli cells and germ cells in the testis. Biol Reprod 1995;52:211–16.

    Article  PubMed  CAS  Google Scholar 

  16. Jegou B. The Sertoli-germ cell communication network in mammals. Int Rev Cytol 1993;147:25–96.

    Article  PubMed  CAS  Google Scholar 

  17. Brinster R, Zimmermann J. Spermatogenesis following male germ-cell transplantation. Dev Biol 1994;91:11298–302.

    CAS  Google Scholar 

  18. Franca L, Ogawa T, Avarbock M, Brinster R, Russell L. Germ cell genotype controls cell cycle during spermatogenesis in the rat. Biol Reprod 1998;59:1371–77.

    Article  PubMed  CAS  Google Scholar 

  19. Ma K, Inglis JD, Bickmore S, Bickmore WA, Speed RM, Thomson EJ, et al. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Cell 1993;75:1287–95.

    Article  PubMed  CAS  Google Scholar 

  20. Reijo R, Lee T-Y, Salo P, Alagappan R, Brown LG, Rosenberg M, et al. Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nat Genet 1995;10:383–93.

    Article  PubMed  CAS  Google Scholar 

  21. Pryor JL, Kent First M, Muallem A, VanBergen AH, Nolten WE, Meisner L. Microdeletions in the Y chromosome of infertile men. N Engl J Med 1997;336:534–39.

    Article  PubMed  CAS  Google Scholar 

  22. Ogura A, Matsuda J, Yanagimachi R. Birth of normal young after electrofusion of mouse oocytes with round spermatids. Proc Natl Acad Sci USA 1994;91:7460–62.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Norman B. Hecht
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Editors and Affiliations

  1. Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL, 60208-3500, USA

    Erwin Goldberg Ph.D.

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© 2000 Springer-Verlag New York, Inc.

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Hecht, N.B. (2000). Spermatogenesis After the Millennium. In: Goldberg, E. (eds) The Testis. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2106-7_2

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  • DOI: https://doi.org/10.1007/978-1-4612-2106-7_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7416-2

  • Online ISBN: 978-1-4612-2106-7

  • eBook Packages: Springer Book Archive

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