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GHRH, GH, and IGF-I pp 75–90Cite as

Effects of Recombinant Human Growth Hormone on Body Composition and Metabolism in HIV-Associated Wasting

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Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

Body wasting is a frequent and potentially devastating accompaniment to infection with human immunodeficiency virus (HIV). Wasting can impair functional performance, immune function, and quality of life and is a factor in survival itself (1, 2). In many patients infected with HIV, death occurs when body cell mass (BCM) is depleted below a level that is critical to sustain life (1), implying that death in these patients may be due to malnutrition per se, rather than to the direct effects of infection and malignancy. The demonstrated associations between loss of body weight or BCM and survival imply that maintenance or restoration of weight or BCM could prolong life in HIV-infected persons (1). Thus, considerable effort has been directed to the search for effective anabolic therapies.

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Authors
  1. K. Mulligan
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  2. C. Grunfeld
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  3. M. K. Hellerstein
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  4. R. A. Neese
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  5. M. Schambelan
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Editor information

Editors and Affiliations

  1. Division of Endocrinology and Metabolism Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA

    Marc R. Blackman M.D.

  2. Division of Geriatric Medicine and Gerontology Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA

    Jesse Roth M.D.  & Jay R. Shapiro M.D.  & 

  3. Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA

    S. Mitchell Harman M.D., Ph.D.

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© 1995 Springer Science+Business Media New York

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Mulligan, K., Grunfeld, C., Hellerstein, M.K., Neese, R.A., Schambelan, M. (1995). Effects of Recombinant Human Growth Hormone on Body Composition and Metabolism in HIV-Associated Wasting. In: Blackman, M.R., Roth, J., Harman, S.M., Shapiro, J.R. (eds) GHRH, GH, and IGF-I. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-0807-5_9

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  • DOI: https://doi.org/10.1007/978-1-4612-0807-5_9

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6908-3

  • Online ISBN: 978-1-4612-0807-5

  • eBook Packages: Springer Book Archive

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