Abstract
Growth hormone (GH) and insulin-like growth factor I (IGF-I) exert effects on intermediary metabolism, and, conversely, the endogenous concentrations and actions of these hormones are influenced by nutritional status. This effect of nutritional status is reflected by the high GH and low IGF-I concentrations seen in malnourished individuals (1), by the observations that during fasting IGF-I concentrations fall to levels similar to those seen in patients with hypopituitarism (2), and by the fact that GH injections fail to raise IGF-I concentrations during fasting (3). Conversely, malnourished subjects exhibit an increase in IGF-I concentration in response to nutritional support therapy, and this rise in IGF-I correlates well with improvements in nitrogen balance (4).
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© 1995 Springer Science+Business Media New York
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Snyder, D.K. (1995). Modulation of Responses to GH and IGF-I by Nutritional Variables. In: Blackman, M.R., Roth, J., Harman, S.M., Shapiro, J.R. (eds) GHRH, GH, and IGF-I. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-0807-5_19
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DOI: https://doi.org/10.1007/978-1-4612-0807-5_19
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