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Procedural Sedation and Anesthesia in the PICU

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Pediatric Critical Care Medicine

Abstract

Critically ill children in the Pediatric Intensive Care Unit (PICU) frequently undergo painful and anxiety-provoking procedures as part of their overall evaluation and management; these may include central line insertion, arterial line placement, chest tube placement, and lumbar puncture. Recently there has been a growing trend towards performing elective diagnostic and therapeutic procedures in children, which formerly required hospitalization, as same-day ambulatory procedures. Procedural sedation is often utilized to facilitate the safe and successful performance of these ambulatory procedures in children, in order to minimize complications and decrease the pain and anxiety associated with them.

Prior to the administration of procedural sedation it is important that adequate preparation has taken place in order to maximize patient safety. Preparation should include a full health evaluation noting the fasting status, performance of a guided risk assessment, assignment of a physical status score, and the generation of a sedation plan. Minimum monitoring standards should be maintained from the administration of sedative agents until the recovery criteria are met.

Non-pharmacological measures can be very useful in alleviating anxiety on the part of the patient and may reduce the need for pharmacological agents. Massage, music, video-viewing, nursery rhymes and story telling are all techniques frequently employed on the PICU during painful procedures.

Pharmacological agents commonly used to facilitate procedural sedation include chloral hydrate, benzodiazepines such as midazolam, ketamine and propofol.

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References

  1. Zeltzer L, Kellerman J, Ellenberg L, et al. Psychologic effects of illness in adolescence. II. Impact of illness in adolescents-crucial issues and coping styles. J Pediatr. 1980;97:132–8.

    Article  PubMed  CAS  Google Scholar 

  2. Kazak AE, Penati B, Boyer BA, et al. A randomized, controlled prospective outcome study of a psychosocial and pharmacological intervention protocol for procedural distress in pediatric leukemia. J Pediatr Psychol. 1996;21:615–31.

    Article  PubMed  CAS  Google Scholar 

  3. Committee on Drugs, American Academy of Pediatrics. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures. Pediatrics. 1992;89:1110–5.

    Google Scholar 

  4. Committee on Drugs, American Academy of Pediatrics. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: addendum. Pediatrics. 2002;110:836–8.

    Article  Google Scholar 

  5. American Academy of Pediatrics, American Academy of Pediatric Dentistry, Cote CJ, Wilson S, Work Group on Sedation. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update. Pediatrics. 2006;118:2587–602.

    Article  PubMed  Google Scholar 

  6. American Society of Anesthesiologists Task Force on Sedation and Analgesia by Non-Anesthesiologists. Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology. 2002;96:1004–17.

    Article  Google Scholar 

  7. Scottish Intercollegiate Guidelines Network. Sign Guideline 58: safe sedation of children undergoing diagnostic and therapeutic procedures. Pediatr Anaesth. 2008;18:11–2.

    Google Scholar 

  8. Hoffman GM, Nowakowski R, Troshynski TJ, et al. Risk reduction in pediatric procedural sedation by application of an American Academy of Pediatrics/American Society of Anesthesiologists process model. Pediatrics. 2002;109:236–43.

    Article  PubMed  Google Scholar 

  9. Vaspasiano M, Finkelstein M, Kurachek S. Propofol sedation: intensivists’ experience with 7304 cases in a children’s hospital. Pediatrics. 2007;120:e1411–7.

    Article  Google Scholar 

  10. Agrawal D, Manzi SF, Gupta R, et al. Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. Ann Emerg Med. 2003;42:636–46.

    Article  PubMed  Google Scholar 

  11. Roback MG, Bajaj L, Wathen JE, et al. Preprocedural fasting and adverse events in procedural sedation and analgesia in a pediatric emergency department: are they related? Ann Emerg Med. 2004;44:454–9.

    Article  PubMed  Google Scholar 

  12. Bell A, Treston G, McNabb C, et al. Profiling adverse respiratory events and vomiting when using propofol for emergency department procedural sedation. Emerg Med Australas. 2007;19:405–10.

    Article  PubMed  Google Scholar 

  13. Thorpe RJ, Benger J. Pre-procedural fasting in emergency sedation. Emerg Med J. 2010;27:254–61.

    Article  PubMed  Google Scholar 

  14. Deitch K, Miner J, Chudnofsky CR, et al. Does end tidal CO2 monitoring during emergency department procedural sedation and analgesia with propofol decrease the incidence of hypoxic events? A randomized, controlled trial. Ann Emerg Med. 2010;55:258–64.

    Article  PubMed  Google Scholar 

  15. Lightdale JR, Goldmann DA, Feldman HA, et al. Microstream capnography improves patient monitoring during moderate sedation: a randomized, controlled trial. Pediatrics. 2006;117:e1170–8.

    Article  PubMed  Google Scholar 

  16. Grindstaff RJ, Tobias JD. Applications of bispectral index monitoring in the pediatric intensive care unit. J Intensive Care Med. 2004;19:111–6.

    Article  PubMed  Google Scholar 

  17. Agrawal D, Feldman HA, Krauss B, et al. Bispectral index monitoring quantifies depth of sedation during emergency department procedural sedation and analgesia in children. Ann Emerg Med. 2004;43:247–55.

    Article  PubMed  Google Scholar 

  18. Langhan ML, Mallory M, Hertzog J, et al. Physiologic monitoring practices during pediatric procedural sedation; a report from the Pediatric Sedation Research Consortium. Arch Pediatr Adolesc Med. 2012;166:990–8.

    Article  PubMed  Google Scholar 

  19. Cravero JP, Blike GT. Review of pediatric sedation. Anesth Analg. 2004;99:1355–64.

    Article  PubMed  Google Scholar 

  20. Cote CJ, Karl HW, Notterman DA, et al. Adverse sedation events in pediatrics: analysis of medications used for sedation. Pediatrics. 2000;106:633–44.

    Article  PubMed  CAS  Google Scholar 

  21. Cote CJ, Notterman DA, Karl HW, et al. Adverse sedation events in pediatrics: a critical incident analysis of contributing factors. Pediatrics. 2000;105:805–14.

    Article  PubMed  CAS  Google Scholar 

  22. Caperell K, Pitetti R. Is higher ASA class associated with an increased incidence of adverse events during procedural sedation in a pediatric emergency department? Pediatr Emerg Care. 2009;25:661–4.

    Article  PubMed  Google Scholar 

  23. Bullock EA, Shaddy RE. Relaxation and imagery techniques without sedation during right ventricular endomyocardial biopsy in pediatric heart transplant patients. J Heart Lung Transplant. 1993;12:59–62.

    PubMed  CAS  Google Scholar 

  24. Koch M, Kain Z, Ayoub C, et al. The sedative and analgesic sparing effects of music. Anesthesiology. 1998;89:300–6.

    Article  PubMed  CAS  Google Scholar 

  25. Stevenson JG, French JW, Tenckhoff L, et al. Video viewing as an alternative to sedation for young subjects who have cardiac ultrasound examinations. J Am Soc Echocardiogr. 1990;3:488–90.

    Article  PubMed  CAS  Google Scholar 

  26. Salmon K, McGuigan F, Pereira JK. Brief report: optimizing children’s memory and management of an invasive medical procedure: the influence of procedural narration and distraction. J Pediatr Psychol. 2006;31:522–7.

    Article  PubMed  Google Scholar 

  27. Uman LS, Chambers CT, McGrath PJ, et al. Psychological interventions for needle-related procedural pain and distress in children and adolescents. Cochrane Database Syst Rev. 2006;4:CD005179.

    PubMed  Google Scholar 

  28. Nilsson S, Finnstrom B, Kokinsky E, et al. The use of Virtual Reality for needle-related procedural pain and distress in children and adolescents in a paediatric oncology unit. Eur J Oncol Nurse. 2009;13:102–9.

    Article  Google Scholar 

  29. Malviya S, Voepel-Lewis T, Prochaska G, et al. Prolonged recovery and delayed side effects of sedation for diagnostic imaging studies in children. Pediatrics. 2000;105:E42.

    Article  PubMed  CAS  Google Scholar 

  30. Wood M. The safety and efficacy of using a concentrated intranasal midazolam formulation for paediatric dental sedation. SAAD Dig. 2011;27:16–23.

    PubMed  Google Scholar 

  31. Chiaretti A, Barone G, Rigante D, et al. Intranasal lidocaine and midazolam for procedural sedation in children. Arch Dis Child. 2011;96:160–3.

    Article  PubMed  Google Scholar 

  32. Singh R, Kumar N, Vajifdar H. Midazolam as a sole sedative for computed tomography imaging in pediatric patients. Pediatr Anesth. 2009;19:899–904.

    Article  Google Scholar 

  33. MCA/CSM. Curr Probl Pharmacovigilance. 2001;27:10.

    Google Scholar 

  34. Vasile B, Rasulo F, Candiani A, et al. The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med. 2003;29:1417–25.

    Article  PubMed  Google Scholar 

  35. Wolf A, Weir P, Segar P, et al. Impaired fatty acid oxidation in propofol infusion syndrome. Lancet. 2001;357:606–7.

    Article  PubMed  CAS  Google Scholar 

  36. Playfor SD, Krishnappa V. Current practice with propofol in PICU in the United Kingdom and the United States. Pediatr Anesth. 2004;14:501–4.

    Article  Google Scholar 

  37. Jenkins IA, Playfor SD, Bevan C, et al. Current United Kingdom sedation practice in pediatric intensive care. Pediatr Anesth. 2007;17:675–83.

    Article  Google Scholar 

  38. Mallory MD, Baxter AL, Yanosky DJ, et al. Pediatric Sedation Research Consortium Emergency physician-administered propofol sedation: a report on 25,433 sedations from the pediatric sedation research consortium. Ann Emerg Med. 2011;57:462–8.

    Article  PubMed  Google Scholar 

  39. Machata A-M, Willschke H, Kabon B, et al. Propofol-based sedation regimen for infants and children undergoing ambulatory magnetic resonance imaging. Br J Anaesth. 2008;101:239–43.

    Article  PubMed  CAS  Google Scholar 

  40. Vespasiano M, Finkelstein M, Kuracheck. Propofol sedation: intensivists’ experience with 7304 cases in a children’s hospital. Pediatrics. 2007;120:e1411–7.

    Article  PubMed  Google Scholar 

  41. Reeves ST, Havidich JE, Tobin DP. Conscious sedation of children with propofol is anything but conscious. Pediatrics. 2004;114:74–6.

    Article  Google Scholar 

  42. Seigler RS, Avant MG, Gwyn DR, et al. A comparison of propofol and ketamine/midazolam for intravenous sedation of children. Pediatr Crit Care Med. 2001;2:20–3.

    Article  PubMed  Google Scholar 

  43. Vardi A, Salem Y, Padeh S, et al. Is propofol safe for procedural sedation in children? A prospective evaluation of propofol versus ketamine in pediatric critical care. Crit Care Med. 2002;30:1231–6.

    Article  PubMed  CAS  Google Scholar 

  44. Griffiths MA, Kamat PP, McCracken CE, et al. Is procedural sedation with propofol acceptable for complex imaging? A comparison of short vs. prolonged sedations in children. Pediatr Radiol. 2013;43:1273–8.

    Google Scholar 

  45. Corssen G, Miyasaka M, Domino EF. Changing concepts of pain control during surgery: dissociative anesthesia with CI-581. Anesth Analg. 1968;47:746–59.

    Article  PubMed  CAS  Google Scholar 

  46. Wyte SR, Shapiro HM, Turner P, et al. Ketamine-induced intracranial hypertension. Anesthesiology. 1972;36:174–6.

    Article  PubMed  CAS  Google Scholar 

  47. Michalczyk K, Sullivan JE, Berkenbosch JW. Pretreatment with midazolam blunts the rise in intracranial pressure associated with ketamine sedation for lumbar puncture in children. Pediatr Crit Care Med. 2013;14:e149–55.

    Article  PubMed  Google Scholar 

  48. Green SM, Denmark TK, Cline J, et al. Ketamine sedation for pediatric critical care procedures. Pediatr Emerg Care. 2001;17:244–8.

    Article  PubMed  CAS  Google Scholar 

  49. Melendez E, Bachur R. Serious adverse events during procedural sedation with ketamine. Pediatr Emerg Care. 2009;25:325–8.

    Article  PubMed  Google Scholar 

  50. Erden IA, Pamuk AG, Akinci SB, et al. Comparison of propofol-fentanyl with propofol-fentanyl-ketamine combination in pediatric patients undergoing interventional radiology procedures. Pediatr Anesth. 2009;19:500–6.

    Article  Google Scholar 

  51. Andolfatto G, Willman E. A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol). Acad Emerg Med. 2010;17:194–201.

    Article  PubMed  Google Scholar 

  52. David H, Shipp J. A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation. Ann Emerg Med. 2011;57:435–41.

    Article  PubMed  Google Scholar 

  53. Malviya S, Voepel-Lewis T, Tait AR, et al. Pentobarbital vs chloral hydrate for sedation of children undergoing MRI: efficacy and recovery characteristics. Pediatr Anesth. 2004;7:589–95.

    Article  Google Scholar 

  54. Bauman LA, Kish I, Baumann RC, et al. Pediatric sedation with analgesia. Am J Emerg Med. 1999;17:1–3.

    Article  PubMed  CAS  Google Scholar 

  55. Berkenbosch JW, Graff GR, Stark JM, et al. Use of a remifentanil-propofol mixture for pediatric flexible fiberoptic bronchoscopy sedation. Paediatr Anaesth. 2004;14:941–6.

    Article  PubMed  Google Scholar 

  56. Reyle-Hahn M, Niggemann B, Max M, et al. Remifentanil and propofol for sedation in children and young adolescents undergoing diagnostic flexible bronchoscopy. Paediatr Anaesth. 2000;10:59–63.

    Article  PubMed  CAS  Google Scholar 

  57. Fahy CJ, Okumura M. Sedation for paediatric stereotactic radiosurgery: the dexmedetomidine experience. Anaesth Intensive Care. 2004;32:809–11.

    PubMed  CAS  Google Scholar 

  58. Zub D, Berkenbosch JW, Tobias JD. Preliminary experience with oral dexmedetomidine for procedural and anesthetic premedication. Paediatr Anaesth. 2005;15:932–8.

    Article  PubMed  Google Scholar 

  59. Tobias JD, Berbenbosch JW. Initial experience with dexmedetomidine in paediatric-aged patients. Paediatr Anaesth. 2002;12:171–5.

    Article  PubMed  Google Scholar 

  60. Heard C, Joshi P, Johnson K. Dexmedetomidine for pediatric MRI sedation: a review of a series of cases. Paediatr Anaesth. 2007;17:888–92.

    Article  PubMed  Google Scholar 

  61. McVey JD, Tobias JD. Dexmedetomidine and ketamine for sedation during spinal anesthesia in children. J Clin Anesth. 2010;22:538–45.

    Article  PubMed  CAS  Google Scholar 

  62. Mason KP, Zurakowski D, Zgleszewski SE, et al. High dose dexmedetomidine as the sole sedative for pediatric MRI. Paediatr Anaesth. 2008;18:403–11.

    Article  PubMed  Google Scholar 

  63. Yuen VM. Dexmedetomidine: perioperative applications in children. Paediatr Anaesth. 2010;20:256–64.

    Article  PubMed  Google Scholar 

  64. Tobias JD, Berkenbosch JW, Russo P. Additional experience with dexmedetomidine in pediatric patients. South Med J. 2003;96:871–5.

    Article  PubMed  Google Scholar 

  65. Siddappa R, Riggins J, Kariyanna S, et al. High-dose dexmedetomidine sedation for pediatric MRI. Paediatr Anaesth. 2011;21:153–8.

    Article  PubMed  Google Scholar 

  66. Hammer GB, Drover DR, Cao H, et al. The Effects of Dexmedetomidine on cardiac electrophysiology in children. Anesth Analg. 2008;106:79–83.

    Article  PubMed  CAS  Google Scholar 

  67. Mason KP, Zurakowski D, Zgleszewski S, et al. Incidence and predictors of hypertension during high-dose dexmedetomidine sedation for pediatric MRI. Paediatr Anaesth. 2010;20:516–23.

    Article  PubMed  Google Scholar 

  68. Mason KP, Zgleszewski SE, Prescillia R, et al. Hemodynamic effects of dexmedetomidine sedation for CT imaging studies. Paediatr Anaesth. 2008;18:393–402.

    Article  PubMed  Google Scholar 

  69. Brown SC, Hart G, Chastain DP, et al. Reducing distress for children during invasive procedures: randomized clinical trial of effectiveness of the PediSedate. Paediatr Anaesth. 2009;19:725–31.

    Article  PubMed  Google Scholar 

  70. Zier JL, Tarrago R, Liu M. Level of sedation with nitrous oxide for pediatric medical procedures. Anesth Analg. 2010;110:1399–405.

    Article  PubMed  CAS  Google Scholar 

  71. Montes RG, Bohn RA. Deep sedation with inhaled sevoflurane for pediatric outpatient gastrointestinal endoscopy. J Pediatr Gastroenterol Nutr. 2000;31:41–6.

    Article  PubMed  CAS  Google Scholar 

  72. Lebovic S, Reich DL, Steinberg LG, et al. Comparison of propofol versus ketamine for anesthesia in pediatric patients undergoing cardiac catheterization. Anesth Analg. 1992;74:490–4.

    Article  PubMed  CAS  Google Scholar 

  73. Mallory MD, Baxter AL, Kost SI, Pediatric Sedation Research Consortium. Propofol vs pentobarbital for sedation of children undergoing magnetic resonance imaging: results from the Pediatric Sedation Research Consortium. Pediatr Anesth. 2009;19:601–11.

    Article  Google Scholar 

  74. Kennedy RM, Porter FL, Miller JP, et al. Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics. 1998;102:956–63.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Stephen D. Playfor MBBS, DCH, MRCP, MRCPCH, DM .

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Playfor, S.D., Kirkpatrick, K. (2014). Procedural Sedation and Anesthesia in the PICU. In: Wheeler, D., Wong, H., Shanley, T. (eds) Pediatric Critical Care Medicine. Springer, London. https://doi.org/10.1007/978-1-4471-6359-6_6

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  • DOI: https://doi.org/10.1007/978-1-4471-6359-6_6

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