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Dermatopathology pp 95–111Cite as

Connective Tissue/Degenerative Disorders

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Abstract

Clinical: Autoimmune disorder of unclear etiology more commonly seen in females and black individuals. Presents with skin tightening and induration with a leathery, often shiny surface as well as alopecia. Areas of involvement include the face, trunk and fingers, and usually are bilateral with distal to proximal progression. Genetics are complex. Risk factors include HLA-DR3 or DR5 and a positive family history. Two subtypes exist: limited and diffuse cutaneous variants.

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Authors and Affiliations

  1. Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Clay Cockerell & Brian J. Hall

  2. Department of Dermatology, Brigham and Women’s Hospital, Boston, MA, USA

    Martin C. Mihm Jr.

  3. Department of Pathology and Dermatopathology, Central Texas Pathology Laboratory, Waco, TX, USA

    Cary Chisholm

  4. Department of Dermatology, Tufts Medical Center, Boston, MA, USA

    Chad Jessup

  5. Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA

    Margaret Merola

Authors
  1. Clay Cockerell
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  2. Martin C. Mihm Jr.
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  3. Brian J. Hall
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  4. Cary Chisholm
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  5. Chad Jessup
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  6. Margaret Merola
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© 2014 Springer-Verlag London

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Cockerell, C., Mihm, M.C., Hall, B.J., Chisholm, C., Jessup, C., Merola, M. (2014). Connective Tissue/Degenerative Disorders. In: Dermatopathology. Springer, London. https://doi.org/10.1007/978-1-4471-5448-8_6

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  • DOI: https://doi.org/10.1007/978-1-4471-5448-8_6

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-5447-1

  • Online ISBN: 978-1-4471-5448-8

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