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Cardiac Arrhythmias pp 19–34Cite as

Molecular Basis of Arrhythmias Associated with the Cardiac Conduction System

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Abstract

The cardiac conduction system is responsible for the initiation and coordination of the heartbeat. It consists of three central components: the sinus node, the atrioventricular node, and the His-Purkinje system. Since the discovery of the sinus node in 1907, the cardiac conduction system has been a topic of immense interest to basic science and clinical researchers investigating the function/dysfunction of the heart. In the last 10 years, our understanding of the system has been immensely enriched. We now know that the system has specialized (different from that in the working myocardium) expression profile of ion channels, intracellular Ca2+-handling proteins, and gap junction channels that are appropriate for its functioning, although there is continued debate concerning the ionic mechanisms underlying pacemaking. We are beginning to understand the mechanisms responsible for cardiac conduction system dysfunction in disease and appreciate how naturally occurring ion channel mutations cause congenital cardiac conduction system dysfunction. In this chapter we present the molecular basis of arrhythmias associated with the cardiac conduction system, with particular emphasis on recent developments in the field.

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Authors and Affiliations

  1. Cardiovascular Research Group, School of BioMedicine, University of Manchester, Manchester, UK

    Sunil Jit R. J. Logantha PhD

  2. Institute of Cardiovascular Sciences, School of BioMedicine, University of Manchester, CTF Building, 46 Grafton Street, Manchester, M13 9NT, UK

    Andrew J. Atkinson, Mark R. Boyett PhD & Halina Dobrzynski PhD

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  1. Sunil Jit R. J. Logantha PhD
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  2. Andrew J. Atkinson
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  3. Mark R. Boyett PhD
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  4. Halina Dobrzynski PhD
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Correspondence to Halina Dobrzynski PhD .

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Editors and Affiliations

  1. Department of Cardiology, Center Hospitalier Coutances, Coutances, France

    Ambrose S. Kibos

  2. Department of Internal Medicine Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

    Bradley P. Knight

  3. Division of Cardiology, McGill University Health Center, Montreal, Québec, Canada

    Vidal Essebag

  4. Department of Cardiology, Miami Children's Hospital, Miami, Florida, USA

    Steven B. Fishberger

  5. School of Biology, Chemistry and Health, Manchester Metropolitan University, Manchester, United Kingdom

    Mark Slevin

  6. “Acad. Vasile Candea” Emergency Clinical Center for Cardiovascular Diseases, “Carol Davila” University of Medicine and Pharmacy, “Titu Maiorescu” University Faculty of Medicine,, Bucharest, Romania

    Ion C. Țintoiu

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Logantha, S.J.R.J., Atkinson, A.J., Boyett, M.R., Dobrzynski, H. (2014). Molecular Basis of Arrhythmias Associated with the Cardiac Conduction System. In: Kibos, A., Knight, B., Essebag, V., Fishberger, S., Slevin, M., Țintoiu, I. (eds) Cardiac Arrhythmias. Springer, London. https://doi.org/10.1007/978-1-4471-5316-0_3

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