Abstract
Most antiarrhythmic drugs act on ion channels and alter the electrical properties of cardiac tissues, which is beneficial for preventing or treating cardiac arrhythmias. This chapter provides a basic understanding of anti-arrhythmic agents, especially on the electrophysiological properties of cardiac excitation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Vaughan Williams EM. A classification of antiarrhythmic actions reassessed after a decade of new drugs. J Clin Pharmacol. 1984;24:129–47.
Vaughan Williams EM. Classification of antiarrhythmic drugs. In: Sandoe E, Flensted-Jensen E, Olsen EH, editors. Symposium on cardiac arrhythmias. Sodertalje: AB Astra; 1970. p. 449–501.
Task Force of the Working Group on Arrhythmias of the European Society of Cardiology. The Sicilian Gambit: a new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Circulation. 1991;84:1831–51.
Hondeghem LM, Katzung BG. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta. 1977;472:373–98.
Hille B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol. 1977;69:497–515.
Belardinelli L, Antzelevitch C, Vos MA. Assessing predictors of drug-induced torsade de pointes. Trends Pharmacol Sci. 2003;2412:619–25.
Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circ Res. 1995;77:140–52.
Lerman BB, Belardinelli L, West GA, Berne RM, DiMarco JP. Adenosine-sensitive ventricular tachycardia: evidence suggesting cyclic AMP-mediated triggered activity. Circulation. 1986;74:270–80.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag London
About this chapter
Cite this chapter
Murakami, S., Kurachi, Y. (2013). Mechanisms of Action of Antiarrhythmic Drugs in Ventricular Arrhythmias. In: Gussak, I., Antzelevitch, C. (eds) Electrical Diseases of the Heart. Springer, London. https://doi.org/10.1007/978-1-4471-4881-4_7
Download citation
DOI: https://doi.org/10.1007/978-1-4471-4881-4_7
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-4880-7
Online ISBN: 978-1-4471-4881-4
eBook Packages: MedicineMedicine (R0)