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Management of Gynecological Cancers in Older Women pp 199–228Cite as

Ovarian Cancer Relapse: Experimental Therapies

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Abstract

Epithe ovarian cancer has the highest mortality of all gynecologic cancers with an estimated 22,280 cases diagnosed in 2012 in the United States and 15,500 deaths [1]. For women between the ages of 60 and 79 years of age, ovarian cancer is the fifth leading cause of cancer death following lung, breast, colorectal, and pancreatic cancer [2]. Survival improvements for newly diagnosed ovarian cancer have reached a plateau using upfront surgery followed by platinum- and taxane-based chemotherapy. Thus, investigational efforts with new therapeutic agents are underway in an effort to overcome platinum- and chemotherapy-resistant cancer and ultimately improve survival. Insights into the molecular biology of ovarian cancer through mechanisms such as The Cancer Genome Atlas Project have identified potential therapeutic targets [2]. Efficacy, toxicities, and drug metabolism related to targeted therapies in the elderly patient with ovarian cancer are not available, and thus, data on the risk-benefit ratio of targeted therapies in this age group are mainly derived from studies in non-gynecologic cancers. This chapter reviews the available targeted therapies for the management of ovarian cancer and outlines the application of newer biologic agents in elderly patients with recurrent ovarian cancer.

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Abbreviations

HTN:

Hypertension

RF:

Renal failure

FDA:

Food and Drug Administration

ATE:

Arterial thromboembolic event

VTE:

Venous thromboembolic event

GIP:

Gastrointestinal perforation

TKI:

Tyrosine kinase inhibitor

IV:

Intravenous

PFS:

Progression-free survival

OS:

Overall survival

PLD:

Pegylated liposomal doxorubicin

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  1. Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, 02215, MA, USA

    Melina Shoni M.D. & Ursula A. Matulonis M.D.

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    Stuart M. Lichtman

  2. University of Liverpool, St Helens Teach, Marshalls Cross Road, St Helens, WA9 3DA, United Kingdom

    Riccardo A. Audisio

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Shoni, M., Matulonis, U.A. (2013). Ovarian Cancer Relapse: Experimental Therapies. In: Lichtman, S., Audisio, R. (eds) Management of Gynecological Cancers in Older Women. Springer, London. https://doi.org/10.1007/978-1-4471-4605-6_13

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