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The Application of Molecular Techniques on Bone Marrow Trephines

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Bone Marrow Lymphoid Infiltrates

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Abstract

Examination of the bone marrow (BM) is a standard diagnostic procedure for the evaluation of patients with malignant lymphoma. Aspiration cytology, flow cytometric immunophenotyping, and the histopathological and immunohistochemical examination of BM biopsies (BMB) are currently the standard examination techniques, in selected cases supplemented with cytogenetics or interphase fluorescence in situ hybridization (FISH) [1–3]. Recent technical advances have allowed the application of ancillary immunohistochemical and molecular techniques to the BMB, which previously was only subjected to conventional histological examination [3, 4].

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  1. Institute of Pathology and Neuropathology, University Hospital Tübingen, Eberhard Karls University, Liebermeisterstrasse 8, D-72076, Tübingen, Germany

    Falko Fend M.D. & Leticia Quintanilla-Martínez M.D.

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  1. Falko Fend M.D.
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Correspondence to Falko Fend M.D. .

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  1. , Department of Hematopathology, Evangelismos Hospital, Ersis Street 9, Athens, 15452, Greece

    Dimitra Anagnostou

  2. Royal Marsden Hospital, Inst. Cancer Research, NHS Foundation Trust, Fulham Road, London, SW3 6JJ, United Kingdom

    Estella Matutes

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Fend, F., Quintanilla-Martínez, L. (2012). The Application of Molecular Techniques on Bone Marrow Trephines. In: Anagnostou, D., Matutes, E. (eds) Bone Marrow Lymphoid Infiltrates. Springer, London. https://doi.org/10.1007/978-1-4471-4174-7_5

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