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The Aging Lymphocyte

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Bone Marrow Lymphoid Infiltrates

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Abstract

The life expectancy in industrialized countries has consistently increased every decade for the last 150 years. From the early 1900s to 2006, the United States alone experienced an increase in life expectancy from 49.2 to 77.7 years [1]. Although most of these increases have occurred in industrialized countries, the world as a whole has also seen improvements. It is projected that, by the year 2025, there will be more than one billion people over the age of 60 worldwide (see World Health Organization website). Increases in life expectancy reflect advances in both public health policy and improved treatments for infectious diseases. However, the increases in average human lifespan also present growing challenges to a nation’s economic, medical, social fabric, and public health programs. Older age is associated with a significantly higher incidence of various chronic conditions, such as cardiovascular disease, cancer, diabetes, neuropathologies, and immune system dysfunction. Persons with these conditions constitute a large burden on the health care system, and in many cases, the lack of adequate treatments have negative effects on quality of life and independent living. Thus, improved understanding of the fundamental molecular basis of aging is critical in order to adequately address the health of an increasingly large proportion of the population.

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Acknowledgments

The authors thank Brenda Molgora for assistance with the artwork. Research described in this chapter has been supported by funds from the National Institutes of Health (AG 023720 and R01AG032422 to RBE) and RevGenetics (to HFV). Dr. Valenzuela is currently a Visiting Scholar at UCLA.

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Authors and Affiliations

  1. Department of Biology, Whittier College, 13406 Philadelphia Street, 634, Whittier, CA, USA

    Hector F. Valenzuela Ph.D.

  2. Department of Pathology and Lab Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA, 90095-1732, USA

    Rita B. Effros Ph.D.

Authors
  1. Hector F. Valenzuela Ph.D.
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  2. Rita B. Effros Ph.D.
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Correspondence to Hector F. Valenzuela Ph.D. or Rita B. Effros Ph.D. .

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  1. , Department of Hematopathology, Evangelismos Hospital, Ersis Street 9, Athens, 15452, Greece

    Dimitra Anagnostou

  2. Royal Marsden Hospital, Inst. Cancer Research, NHS Foundation Trust, Fulham Road, London, SW3 6JJ, United Kingdom

    Estella Matutes

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© 2012 Springer-Verlag London

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Valenzuela, H.F., Effros, R.B. (2012). The Aging Lymphocyte. In: Anagnostou, D., Matutes, E. (eds) Bone Marrow Lymphoid Infiltrates. Springer, London. https://doi.org/10.1007/978-1-4471-4174-7_2

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  • DOI: https://doi.org/10.1007/978-1-4471-4174-7_2

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