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Human Fetal Tissue Transplantation pp 219–235Cite as

Fetal Liver Cell Transplantation

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Abstract

Fetal liver cell transplantation is a promising technique and is entering its clinical application phase. Temporary support of liver function is clearly obtained, and short-term benefit can be achieved for patients. The challenge is to obtain long-term efficacy and demonstrate engraftment and repopulation of the recipient liver. Numerous animal studies have been performed; however, there are many challenging issues that remain to be solved, including increasing engraftment and repopulation and in vitro cell expansion. This knowledge can be used to improve the function of hepatocyte-like cells for drug testing, bioartificial livers, and transplantation.

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Authors and Affiliations

  1. Department of Transplantation Surgery, Sahlgrenska University Hospital, Bruna Stråket 20, 413 45, Gothenburg, Sweden

    Suchitra Sumitran-Holgersson, Meghnad Joshi & Michael Olausson

  2. Sahlgrenska Academy, University of Gothenburg, S-413 45, Gothenburg, Sweden

    Suchitra Sumitran-Holgersson, Meghnad Joshi & Michael Olausson

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  1. Suchitra Sumitran-Holgersson
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  2. Meghnad Joshi
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  3. Michael Olausson
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Correspondence to Suchitra Sumitran-Holgersson .

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  1. Southend Park 55, Kolkata, 700029, India

    Niranjan Bhattacharya

  2. Dept. Obstetrics & Gynaecology, Boston University Medical Centre, E. Concord Street 85, Boston, 02118, Massachusetts, USA

    Phillip Stubblefield

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Sumitran-Holgersson, S., Joshi, M., Olausson, M. (2013). Fetal Liver Cell Transplantation. In: Bhattacharya, N., Stubblefield, P. (eds) Human Fetal Tissue Transplantation. Springer, London. https://doi.org/10.1007/978-1-4471-4171-6_17

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