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Human Fetal Tissue Transplantation pp 185–192Cite as

Fetal Cell Therapy and Tissue Engineering for Musculoskeletal Tissues

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Abstract

Cultured primary fetal cells from one organ donation could possibly meet the exigent and stringent technical aspects for development of therapeutic products. These cell types have fewer technological limitations for cellular proliferation capacity (simple culture conditions) and maintenance of differentiated phenotype, and they also have low probability for transmission of communicable diseases since they can be manufactured using traditional cell banking platforms. Master and working cell banks (MCB, WCB) can be obtained from one fetal organ donation, permitting multiple tissues (skin, bone, cartilage, muscle, and intervertebral disc) to be processed in short periods of time with identical methods to assure a stringent tracing of the processes for the production of standardized therapeutic agents. In addition, specific cell delivery systems for each tissue type can be adapted to the clinical application. Since it is the intention that banked primary fetal cells enhance the prospective treatment of hundreds of thousands of patients with only one organ donation, it is imperative to show consistency, traceability, and safety of the processes including donor tissue selection, cell banking, cell testing, and growth of cells in outscaling for the preparation of bioengineered products for clinical application.

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Author information

Authors and Affiliations

  1. Unit of Regenerative Therapy, Department of Musculoskeletal Medicine (DAL), University Hospital of Lausanne (CHUV-UNIL), Lausanne, Switzerland

    Nathalie Hirt-Burri

  2. Department of Musculoskeletal Medicine (DAL), University Hospital of Lausanne (CHUV-UNIL), Lausanne, Switzerland

    Lee Ann Applegate

  3. Unit of Regenerative Therapy, Department of Musculoskeletal Medicine (DAL), Service of Plastic and Reconstructive Surgery, University Hospital of Lausanne (CHUV-UNIL), CHUV, PAV 03, Lausanne, 1011, Switzerland

    Lee Ann Applegate

Authors
  1. Nathalie Hirt-Burri
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  2. Lee Ann Applegate
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Correspondence to Lee Ann Applegate .

Editor information

Editors and Affiliations

  1. Southend Park 55, Kolkata, 700029, India

    Niranjan Bhattacharya

  2. Dept. Obstetrics & Gynaecology, Boston University Medical Centre, E. Concord Street 85, Boston, 02118, Massachusetts, USA

    Phillip Stubblefield

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© 2013 Springer-Verlag London

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Hirt-Burri, N., Applegate, L.A. (2013). Fetal Cell Therapy and Tissue Engineering for Musculoskeletal Tissues. In: Bhattacharya, N., Stubblefield, P. (eds) Human Fetal Tissue Transplantation. Springer, London. https://doi.org/10.1007/978-1-4471-4171-6_14

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  • DOI: https://doi.org/10.1007/978-1-4471-4171-6_14

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-4170-9

  • Online ISBN: 978-1-4471-4171-6

  • eBook Packages: MedicineMedicine (R0)

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