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Transplantation Surgery pp 235–248Cite as

Small Bowel Transplantation: the New Frontier in Organ Transplantation

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Part of the book series: Springer Specialist Surgery Series ((SPECIALIST))

Abstract

The last ten years have witnessed the emergence of small bowel transplantation (SBT) as a viable treatment modality for selected patients with intestinal failure. The introduction of effective immunosuppressive medications was the most important factor in allowing transplantation of this “forbidden organ”. The technical aspects of harvesting and transplanting the intestine were studied early in the century by Alexis Carrel and later refined by Lillehei and colleagues [1] at the University of Minnesota in 1955. Monchick and Russell [2] established a rat model for SBT which opened the door for investigators to explore unidirectional immune phenomena as well as physiologic function of the transplanted gut. All seven attempts at SBT in humans that were made prior to the introduction of cyclosporine failed because grafts were lost to early rejection or sepsis. Experience with SBT under cyclosporine immunosuppression was encouraging, but ultimately proved to be unsatisfactory as graft loss to rejection continued to be inevitable. Success in human SBT hinged on the advent of FK506 (tacrolimus), which has shown to be of great promise in liver and experimental SBT.

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Authors
  1. Michel M. Murr
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  2. Michael G. Sarr
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Editor information

Editors and Affiliations

  1. St Mary’s Hospital, Praed Street, W2 1NY, London, UK

    Nadey S. Hakim MD, PhD, FRCS, FRCSI, FACS, FICS (Consultant General and Transplant Surgeon, Surgical Director Transplant Unit) (Consultant General and Transplant Surgeon, Surgical Director Transplant Unit)

  2. Kidney & Pancreas Transplant Programs, BH-427 Center for the Health Sciences, UCLA School of Medicine, Box 951796, 90095-1796, Los Angeles, CA, USA

    Gabriel M. Danovitch MD (Professor of Medicine) (Professor of Medicine)

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© 2001 Springer-Verlag London

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Murr, M.M., Sarr, M.G. (2001). Small Bowel Transplantation: the New Frontier in Organ Transplantation. In: Hakim, N.S., Danovitch, G.M. (eds) Transplantation Surgery. Springer Specialist Surgery Series. Springer, London. https://doi.org/10.1007/978-1-4471-3689-7_11

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  • DOI: https://doi.org/10.1007/978-1-4471-3689-7_11

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84996-859-1

  • Online ISBN: 978-1-4471-3689-7

  • eBook Packages: Springer Book Archive

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