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Malignant Mesothelioma: Genetic Susceptibility

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Occupational Cancers

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Abstract

Although exposure to asbestos fibers is a well-known risk factor for malignant mesothelioma (MM), its mechanisms of carcinogenicity are not fully understood. Inhaled asbestos fibers penetrate the lung epithelium and irritate the pleural lining. This causes repeated cycles of damage, repair, and local inflammation. After interaction with mesothelial cells, asbestos triggers multiple cell-signaling pathways.

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Authors and Affiliations

  1. Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, Helsinki, 00250, Finland

    Ari P. Hirvonen PhD

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  1. Ari P. Hirvonen PhD
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Correspondence to Ari P. Hirvonen PhD .

Editor information

Editors and Affiliations

  1. Helsinki University Central Hospital and Finnish Institute of Occupational Health, Helsinki, Finland

    Sisko Anttila

  2. Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Paolo Boffetta

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© 2014 Springer-Verlag London

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Hirvonen, A.P. (2014). Malignant Mesothelioma: Genetic Susceptibility. In: Anttila, S., Boffetta, P. (eds) Occupational Cancers. Springer, London. https://doi.org/10.1007/978-1-4471-2825-0_18

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  • DOI: https://doi.org/10.1007/978-1-4471-2825-0_18

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2824-3

  • Online ISBN: 978-1-4471-2825-0

  • eBook Packages: MedicineMedicine (R0)

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