Chapter

Infected Total Joint Arthroplasty

pp 193-211

Date:

Molecular Diagnosis of Prosthetic Joint Infection

  • Jaime EstebanAffiliated withBone and Joint Infection Unit, Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz
  • , Diana Molina-MansoAffiliated withBone and Joint Infection Unit, Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz
  • , Gema del-PradoAffiliated withBone and Joint Infection Unit, Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz
  • , Enrique Gómez-BarrenaAffiliated withDepartment of Orthopaedic Surgery and Traumatology, Hospital “La Paz” Email author 

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Abstract

Diagnosis of Prosthetic Joint Infection remains as a challenge in modern medicine. Conventional techniques lead to the diagnosis of many patients with a classical infectious syndrome, but differential diagnosis with other entities (particularly aseptic failure) is still a problem. Several molecular markers have been studied in the diagnosis of infection (like cytokines, procalcitonin, specific IgG, sICAM-1, VEGF or alpha2-Macroglobulin), and even for microbiological diagnosis (lipid S, PIA, icaADBC operon), with variable success. PCR-based genetic amplification procedures have also been studied for the detection of microbial genes in different clinical samples, and will be probably included in the next future as part of the diagnostic schemes for this kind of infections.

Keywords

Diagnosis Markers Antigens Genes Polymerase Chain reaction