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Influence of Wear Particles on Local and Systemic Immune System

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Infected Total Joint Arthroplasty

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Abstract

Decreasing periprosthetic osteolysis due to wear particles is a current challenge and an on-going research endeavor to prolong the longevity of joint replacements. The aim of this chapter is to provide the reader keys to the understanding of how the immune system interacts with metallic and non metallic wear particles and other byproducts from joint replacements. The local and systemic immune system is involved in a complex network of chemokines, cytokines, and different cell types which in the end leads to inflammation and a foreign body reaction.

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Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Stanford University School of Medicine, 300 Pasteur Dr, Edwards Bldg. R116, Stanford, CA, 94305, USA

    Emmanuel Gibon M.D.

  2. Department of Orthopaedic Surgery, Bichat Teaching Hospital, Paris School of Medicine, Paris VII University, Paris, France

    Emmanuel Gibon M.D.

  3. Department of Orthopaedic Surgery, Stanford University School of Medicine, 450 Broadway Street M/C 6342, Redwood City, CA, 94063, USA

    Stuart B. Goodman M.D., Ph.D.

Authors
  1. Emmanuel Gibon M.D.
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  2. Stuart B. Goodman M.D., Ph.D.
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Correspondence to Emmanuel Gibon M.D. .

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Editors and Affiliations

  1. Orthopedic Hospital Valdoltra, Ankaran, 6280, Koper, Slovenia

    Rihard Trebše

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Gibon, E., Goodman, S.B. (2012). Influence of Wear Particles on Local and Systemic Immune System. In: Trebše, R. (eds) Infected Total Joint Arthroplasty. Springer, London. https://doi.org/10.1007/978-1-4471-2482-5_13

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  • DOI: https://doi.org/10.1007/978-1-4471-2482-5_13

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