Abstract
This chapter describes and illustrates a range of minor changes that can be observed relatively frequently in the pancreas. Most of these alterations are believed to develop in response to physiological changes, mild injury, or aging. The significance of these changes lies, therefore, in their correct identification and distinction from clinically more relevant lesions. However, recently, a few of these common changes have been implicated in the development of ductal adenocarcinoma of the pancreas, as either a possible progenitor lesion or a sentinel change. The molecular mechanisms underlying the development of these apparently minor changes are currently being actively researched.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Brune K, Abe T, Canto M, O’Malley L, Klein AP, Maitra A, et al. Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol. 2006;30:1067–76.
Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch Pathol Lab Med. 2009;133:365–74.
Makay O, Kazimi M, Aydin U, Nart D, Yilmaz F, Zeytunlu M, et al. Fat replacement of the malignant pancreatic tissue after neoadjuvant therapy. Int J Clin Oncol. 2010;15:88–92.
Stamm BH. Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease. Hum Pathol. 1984;15:677–83.
Further Reading
Reichert M, Rustgi AK. Pancreatic ductal cells in development, regeneration, and neoplasia. J Clin Invest. 2011;121:4572–8.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag London
About this chapter
Cite this chapter
Campbell, F., Verbeke, C.S. (2013). Common Minor Changes. In: Pathology of the Pancreas. Springer, London. https://doi.org/10.1007/978-1-4471-2449-8_5
Download citation
DOI: https://doi.org/10.1007/978-1-4471-2449-8_5
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-2448-1
Online ISBN: 978-1-4471-2449-8
eBook Packages: MedicineMedicine (R0)