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Acinar Cell Carcinoma

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Book cover Pathology of the Pancreas

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Abstract

Acinar cell carcinoma is a rare malignant epithelial neoplasm, composed of cells which morphologically resemble acinar cells and produce pancreatic enzymes. It is totally unrelated to acinar cell nodules or the benign entity acinar cell cystadenoma, both of which are discussed elsewhere in the book. Acinar cell carcinoma may show a wide range of morphological appearances, ranging from well-differentiated acinar structures to solid sheets of poorly differentiated cells, which can cause diagnostic difficulty. These macroscopic and histological features of acinar cell carcinoma and its variants are discussed. There is also detailed discussion of the differential diagnosis and the morphological features and immunohistochemical profiles (tabulated in Chap. 20) which can be used to distinguish these different diagnostic entities.

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Further Reading

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  • Klimstra DS, Hruban RH, Klöppel G, Morohoshi T, Ohike N. Acinar cell neoplasms of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumours of the digestive system, World Health Organization Classification of tumours. Lyon: IARC; 2010. p. 314–8, chapter 12.

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  • Morohoshi T, Hruban RH, Klimstra DS, Ohike N, Terris B. World Health Organization classification of tumours. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumours of the digestive system. Lyon: IARC; 2010. p. 319–21, chapter 12.

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Authors and Affiliations

  1. Department of Pathology, Royal Liverpool University Hospital, Liverpool, UK

    Fiona Campbell

  2. Karolinska Institute, Division of Pathology, Karolinska University Hospital, Stockholm, Sweden

    Caroline S. Verbeke

Authors
  1. Fiona Campbell
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  2. Caroline S. Verbeke
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© 2013 Springer-Verlag London

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Campbell, F., Verbeke, C.S. (2013). Acinar Cell Carcinoma. In: Pathology of the Pancreas. Springer, London. https://doi.org/10.1007/978-1-4471-2449-8_10

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  • DOI: https://doi.org/10.1007/978-1-4471-2449-8_10

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2448-1

  • Online ISBN: 978-1-4471-2449-8

  • eBook Packages: MedicineMedicine (R0)

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