Skip to main content

Breathlessness

  • Chapter
  • First Online:
  • 1434 Accesses

Abstract

Breathlessness is a complex symptom, incorporating physical and emotional components. After considering the control of respiration, the causes of breathlessness and mechanisms in chronic lung disease are described. The assessment of the breathlessness patient can include symptom scoring, measures of the impact on life, descriptors of the sensation and functional measures. Management is initially by disease modification of the underlying process, but alongside this, pharmacological and non-pharmacological interventions may be included. The principal drugs employed are opioids and benzodiazepines. There are a variety of non-drug interventions that are used for dyspnea in lung disease, some including an exercise component, some not. Oxygen also has a role in the hypoxemic patient. The ­presence of breathlessness can also have prognostic significance in advanced lung disease.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. American Thoracic Society. Dyspnea, mechanisms, assessment and management: a consensus statement. Am J Respir Crit Care Med. 1999;159:321–40.

    Google Scholar 

  2. El-Manshawi A, Killian KJ, Summers E, Jones NL. Breathlessness during exercise with and without resistive loading. J Appl Physiol. 1986;61:896–905.

    PubMed  CAS  Google Scholar 

  3. Solano JP, Gomes B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manage. 2006;31:58–69.

    Article  PubMed  Google Scholar 

  4. Dudgeon DJ, Kristjanson L, Sloan JA, Lertzman M, Clement K. Dyspnea in cancer patients: prevalence and associated factors. J Pain Symptom Manage. 2001;21:95–102.

    Article  PubMed  CAS  Google Scholar 

  5. Kozu R, Jenkins S, Senjyu H. Characteristics and disability in individuals with idiopathic pulmonary fibrosis (IPF) stratified by medical research council (MRC) dyspnoea grade. Respirology. 2011;16:1323–9.

    Article  Google Scholar 

  6. Fairburn AJ, Wood CH, Fletcher CM. Variability in answers to a questionnaire on respiratory symptoms. Br J Prev Soc Med. 1959;13:175–93.

    Google Scholar 

  7. Dorman S, Jolley C, Abernethy A, et al. Researching breathlessness in palliative care: consensus statement of the National Cancer Research Institute Palliative Care Breathlessness Subgroup. Palliat Med. 2009;23:213–27.

    Article  PubMed  CAS  Google Scholar 

  8. Mahler D. Mechanisms and measurement of dyspnea in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006;3:234–8.

    Article  PubMed  Google Scholar 

  9. Wilcock A, Crosby V, Hughes A, et al. Descriptors of breathlessness in patients with cancer and other cardiorespiratory diseases. J Pain Symptom Manage. 2002;23:182–9.

    Article  PubMed  Google Scholar 

  10. Gift AG, Narsavage G. Validity of the numeric rating scale as a measure of dyspnea. Am J Crit Care. 1998;7:200–4.

    PubMed  CAS  Google Scholar 

  11. Guyatt GH, Berman LB, Townsend M, Pugsley SO, Chambers LW. A measure of quality of life for clinical trials in chronic lung disease. Thorax. 1987;42:773–8.

    Article  PubMed  CAS  Google Scholar 

  12. American Thoracic Society. ATS statement: guidelines for six-minute walk test. Am J Respir Crit Care Med. 2002;166:111–7.

    Google Scholar 

  13. Wilcock A, Crosby D, Clarke D, Corcoran R, Tattersfield A. Reading numbers aloud – a measure of the limiting effect of breathlessness in patients with cancer. Thorax. 1999;54:1099–103.

    Article  PubMed  CAS  Google Scholar 

  14. Jennings A-L, Davies AN, Higgins JPT, Gibbs JSR, Broadley KE. A systematic review of the use of opioids in the management of dyspnoea. Thorax. 2002;57:939–44.

    Article  PubMed  Google Scholar 

  15. Abernethy AP, Currow DC, Frith P, et al. Randomised, double blind, placebo controlled ­crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ. 2003;327:523–6.

    Article  PubMed  CAS  Google Scholar 

  16. Currow DC, McDonald C, Oaten S, et al. Once daily opioids for chronic dyspnea: a dose ­increment and pharmacovigilance study. J Pain Symptom Manage. 2011;42:388–99.

    Article  PubMed  CAS  Google Scholar 

  17. Simon ST, Higginson IJ, Booth S, Harding R, Bausewein C. Benzodiazepines for the relief of breathlessness in advanced disease in adults. Cochrane Database Syst Rev. 2010;(1).DOI:10.1002/14652858.CD007354.pub2.

    Google Scholar 

  18. Bausewein C, Booth S, Gysels M, Higginson IJ. Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases (review). The Cochrane Library 2009;(3). DOI:10.1002/14651858.CD005623.pub2.

    Google Scholar 

  19. Galbraith S, Fagan P, Perkins P, Lynch A, Booth S. Does the use of a handheld fan improve chronic dyspnea? A randomised controlled, crossover trial. J Pain Symptom Manage. 2010;39:831–8.

    Article  PubMed  Google Scholar 

  20. Corner J, Plant H, A’Hern R, Bailey C. Non-pharmacological intervention for breathlessness in lung cancer. Palliat Med. 1996;10:299–305.

    Article  PubMed  CAS  Google Scholar 

  21. Bredin M, Corner J, Krishnasamy M, et al. Multicentre randomised controlled trial of nursing intervention for breathlessness in patients with lung cancer. Br Med J. 1999;318:901–4.

    Article  CAS  Google Scholar 

  22. Connors S, Graham S, Peel T. An evaluation of a physiotherapy-led non-pharmacological breathlessness programme for patients with intrathoracic malignancy. Palliat Med. 2007;21:285–7.

    Article  PubMed  Google Scholar 

  23. Wood H, Connors S, Dogan S, Peel T. Individual experiences and impacts of a physiotherapist-led, non-pharmacological, breathlessness programme for patients with intrathoracic malignancy – a qualitative study. Palliat Med. 2012. doi:10.177/0269216312464093. Accessed 5 Nov 2012.

  24. British Thoracic Society Standards of Care Subcommittee on Pulmonary Rehabilitation. Pulmonary rehabilitation. Thorax. 2001;56:827–34.

    Article  Google Scholar 

  25. Donner CF, Muir JF. Rehabilitation and Chronic Care Scientific Group of the European Respiratory Society. Selection criteria and programmes for pulmonary rehabilitation in COPD patients. Eur Respir J. 1997;10:744–57.

    PubMed  CAS  Google Scholar 

  26. Lacasse Y, Goldstein R, Lasserson TJ, Martin S. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Review. 2009; Cochrane Collaboration. DOI:10.1002/16511858.CD003793.pub2.

    Google Scholar 

  27. Abernethy AP, McDonald CF, Frith PA, et al. Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double–blind, randomised ­controlled trial. Lancet. 2010;376:784–93.

    Article  PubMed  Google Scholar 

  28. Booth S, Silvester S, Todd C. Breathlessness in cancer and chronic obstructive pulmonary disease: using a qualitative approach to describe the experience of patients and carers. Palliat Support Care. 2003;1:337–44.

    PubMed  Google Scholar 

  29. Pashall MB, Schwartzstein RM, Adams L, et al. An official American Thoracic Society Statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med. 2012;185:432–52.

    Google Scholar 

  30. Prognostic Indicator Guidance (PIG). 4th ed. 2011.www.goldstandardsframework.org.uk. Accessed 1 Apr 2012.

  31. Celli BR, Cote CG, Marin JM, et al. The Body-mass index, airflow Obstruction, Dyspnea, and Exercise capacity (BODE) index in chronic obstructive pulmonary disease. N Engl J Med. 2004;350:1005–11.

    Article  PubMed  CAS  Google Scholar 

  32. Vigano A, Dorgan M, Buckingham J, et al. Survival prediction in terminal cancer patients: a systematic review of the medical literature. Palliat Med. 2000;14:363–74.

    Article  PubMed  CAS  Google Scholar 

  33. Marie Curie Palliative Care Institute. Liverpool care pathway for the dying patient. 2009.http://www.liv.ac.uk/mcpcil/liverpool-care-pathway/. Accessed 1 Apr 2012.

  34. Edmonds P, Higginson I, Altmann D, Sen-gupta G, McDonnell M. Is the presence of dyspnea a risk factor for morbidity in cancer patients? J Pain Symptom Manage. 2000;19:15–22.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. Timothy Peel M.B.B.S., B.Sc., FRCP .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag London

About this chapter

Cite this chapter

Peel, E.T., Burns, G.P. (2013). Breathlessness. In: Bourke, S., Peel, E. (eds) Integrated Palliative Care of Respiratory Disease. Springer, London. https://doi.org/10.1007/978-1-4471-2230-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-2230-2_2

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2229-6

  • Online ISBN: 978-1-4471-2230-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics