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Diffuse Low-Grade Gliomas in Adults pp 1–5Cite as

Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Diffuse Low-Grade Gliomas

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Abstract

Recent technical and conceptual advances in genetics, cognitive neurosciences, imaging, and treatments revolutionized the understanding of diffuse low-grade glioma, leading to the inhibition of dogmas and to the fundamental principle of personalized management.

Moreover, a better knowledge of brain processing enables now to take into consideration interaction between the disease (the glioma) and the host (the brain) and thus to modulate the dynamic therapeutic strategies with the goal to increase the median survival as well as to improve the quality of life - that is, to move toward a “functional neurooncology”. In the era of “evidence-based medicine,” it is crucial to not forget “individual-based medicine.”

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References

  1. Duffau H. Lessons from brain mapping in surgery for low-grade glioma: insights into associations between tumour and brain plasticity. Lancet Neurol. 2005;4:476–86.

    Article  PubMed  Google Scholar 

  2. Mandonnet E, Delattre JY, Tanguy ML, Swanson KR, Carpentier AF, Duffau H, et al. Continuous growth of mean tumor diameter in a subset of grade II gliomas. Ann Neurol. 2003;53:524–8.

    Article  PubMed  Google Scholar 

  3. Pallud J, Mandonnet E, Duffau H, Kujas M, Guillevin R, Galanaud D, et al. Prognostic value of initial magnetic resonance imaging growth rates for World Health Organization grade II gliomas. Ann Neurol. 2006;60:380–3.

    Article  PubMed  Google Scholar 

  4. Yordanova Y, Moritz-Gasser S, Duffau H. Awake surgery for WHO grade II gliomas within “noneloquent” areas in the left dominant hemisphere: toward a “supratotal” resection. J Neurosurg. 2011;115:232–9.

    Article  PubMed  Google Scholar 

  5. Duffau H. Surgery of low-grade gliomas: towards a “functional neurooncology”. Curr Opin Oncol. 2009;21:543–9.

    Article  PubMed  Google Scholar 

  6. Marko NF, Weil RJ. A case for reclassifying infiltrating gliomas in adults. J Neurooncol. 2012;109(3):587–91.

    Article  PubMed  Google Scholar 

  7. Klein M, Duffau H, De Witt Hamer PC. Cognition and resective surgery for diffuse infiltrative glioma: an overview. J Neurooncol. 2012;108:309–18.

    Article  PubMed  Google Scholar 

  8. Douw L, Klein M, Fagel SS, van den Heuvel J, Taphoorn MJ, Aaronson NK, et al. Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up. Lancet Neurol. 2009;8:810–8.

    Article  PubMed  Google Scholar 

  9. Pallud J, Taillandier L, Capelle L, Fontaine D, Peyre M, Ducray F, et al. Quantitative morphological MRI follow-up of low-grade glioma: a plead for systematic measurement of growth rates. Neurosurgery. 2012;71(3):729–39.

    Article  PubMed  Google Scholar 

  10. Macdonald DR, Cascino TL, Schold SC, Cairncross JG. Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol. 1990;8:1277–80.

    PubMed  CAS  Google Scholar 

  11. van den Bent MJ, Wefel JS, Schiff D, Taphoorn MJ, Jaeckle K, Junck L, et al. Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas. Lancet Oncol. 2011;12:583–93.

    Article  PubMed  Google Scholar 

  12. Duffau H, Lopes M, Arthuis F, Bitar A, Sichez JP, Van Effenterre R, et al. Contribution of intraoperative electrical stimulations in surgery of low grade gliomas: a comparative study between two series without (1985–96) and with (1996–2003) functional mapping in the same institution. J Neurol Neurosurg Psychiatry. 2005;76:845–51.

    Article  PubMed  CAS  Google Scholar 

  13. Smith JS, Chang EF, Lamborn KR, Chang SM, Prados MD, Cha S, et al. Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. J Clin Oncol. 2008;26:1338–45.

    Article  PubMed  Google Scholar 

  14. Capelle L, Fontaine D, Mandonnet E, Taillandier L, Golmard JL, Bauchet L, et al. Spontaneous and ­therapeutic prognostic factors in adult hemispheric WHO grade II gliomas: a series of 1097 cases. J Neurosurg (in press).

    Google Scholar 

  15. De Witt Hamer PC, Gil Robles S, Zwinderman AH, Duffau H, Berger MS. Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis. J Clin Oncol. 2012;30(20):2559–65.

    Article  PubMed  Google Scholar 

  16. Duffau H. The challenge to remove diffuse low-grade gliomas while preserving brain functions. Acta Neurochir (Wien). 2012;154:569–74.

    Article  Google Scholar 

  17. Duffau H, editor. Brain mapping: from neural basis of cognition to surgical applications. Wien/New York: Springer; 2011.

    Google Scholar 

  18. Gil Robles S, Gatignol P, Lehéricy S, Duffau H. Long-term brain plasticity allowing multiple-stages surgical approach for WHO grade II gliomas in eloquent areas: a combined study using longitudinal functional MRI and intraoperative electrical stimulation. J Neurosurg. 2008;109:615–24.

    Article  Google Scholar 

  19. Blonski M, Taillandier L, Herbet G, Maldonado IL, Beauchesne P, Fabbro M, et al. Combination of ­neoadjuvant chemotherapy followed by surgical resection as new strategy for WHO grade II gliomas: a study of cognitive status and quality of life. J Neurooncol. 2012;106:353–66.

    Article  PubMed  CAS  Google Scholar 

  20. Kim YH, Nobusawa S, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, et al. Molecular classification of low-grade diffuse gliomas. Am J Pathol. 2010;177:2708–14.

    Article  PubMed  Google Scholar 

  21. Duffau H. Awake surgery for incidental WHO grade II gliomas involving eloquent areas. Acta Neurochir. 2012;154:575–84.

    Article  PubMed  Google Scholar 

  22. Pallud J, Fontaine D, Duffau H, Mandonnet E, Sanai N, Taillandier L, et al. Natural history of ­incidental World Health Organization grade II gliomas. Ann Neurol. 2010;68:727–33.

    Article  PubMed  Google Scholar 

  23. Potts MB, Smith JS, Molinaro AM, Berger MS. Natural history and surgical management of incidentally discovered low-grade gliomas. J Neurosurg. 2012;116:326–72.

    Google Scholar 

  24. Duffau H. A new concept of diffuse (low-grade) glioma surgery. Adv Tech Stand Neurosurg. 2012;38:3–27.

    Article  PubMed  CAS  Google Scholar 

  25. Rigau V, Zouaoui S, Mathieu-Daudé H, Darlix A, Maran A, Trétarre B, et al. French brain tumor database: 5-year histological results on 25 756 cases. Brain Pathol. 2011;21:633–44.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France

    Hugues Duffau MD, PhD

  2. National Institute for Health and Medical Research (INSERM), U1051 Laboratory, Team “Brain Plasticity, Stem Cells and Glial Tumors”, Institute for Neurosciences of Montpellier, Montpellier University Medical Center, 34091, Montpellier, France

    Hugues Duffau MD, PhD

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  1. Hugues Duffau MD, PhD
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Correspondence to Hugues Duffau MD, PhD .

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Editors and Affiliations

  1. , INSERM U1051, Institute for Neurosciences of Montpelli, av. Augustin Fliche 80, Montpellier, 34295, France

    Hugues Duffau

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© 2013 Springer-Verlag London

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Duffau, H. (2013). Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Diffuse Low-Grade Gliomas. In: Duffau, H. (eds) Diffuse Low-Grade Gliomas in Adults. Springer, London. https://doi.org/10.1007/978-1-4471-2213-5_1

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  • DOI: https://doi.org/10.1007/978-1-4471-2213-5_1

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2212-8

  • Online ISBN: 978-1-4471-2213-5

  • eBook Packages: MedicineMedicine (R0)

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