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Epigenetic Targeting Therapies to Overcome Chemotherapy Resistance

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Epigenetic Alterations in Oncogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((volume 754))

Abstract

It is now well established that epigenetic aberrations occur early in malignant transformation, raising the possibility of identifying chemopreventive compounds or reliable diagnostic screening using epigenetic biomarkers. Combinatorial therapies effective for the reexpression of tumor suppressors, facilitating resensitization to conventional chemotherapies, hold great promise for the future therapy of cancer. This approach may also perturb cancer stem cells and thus represent an effective means for managing a number of solid tumors. We believe that in the near future, anticancer drug regimens will routinely include epigenetic therapies, possibly in conjunction with inhibitors of “stemness” signal pathways, to effectively reduce the devastating occurrence of cancer chemotherapy resistance.

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Acknowledgments

The authors affirm no conflict of interest regarding any of the content of this manuscript. The authors gratefully acknowledge grant support from the United States National Institutes of Health, National Cancer Institute awards CA085289, CA113001, the Ovarian Cancer Research Foundation [PPD/IU/01.2011] (New York, NY), the American Cancer Society Indiana University Research Grant #84-002-25, the Walther Cancer Foundation (Indianapolis, IN), and Ovar’coming Together, Inc. (Indianapolis, IN).

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Authors and Affiliations

  1. Medical Sciences, Indiana University School of Medicine, Indiana University School of Medicine, Jordan Hall 300; 1001 East Third Street, Bloomington, IN, 47405, USA

    Curt Balch

  2. Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, 46202, USA

    Curt Balch & Kenneth P. Nephew

  3. Medical Sciences, Indiana University School of Medicine, Bloomington, IN, 47405, USA

    Kenneth P. Nephew

  4. Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA

    Kenneth P. Nephew

  5. Department of Obstetrics and Gynecology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA

    Kenneth P. Nephew

  6. Medical Sciences Program, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Jordan Hall 302; 1001 East Third Street, Bloomington, IN, 47405, USA

    Kenneth P. Nephew

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  1. Curt Balch
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  2. Kenneth P. Nephew
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Correspondence to Kenneth P. Nephew .

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  1. University of Nebraska Medical Center, Eppley Institute for Research in Cancer, 985950 Nebraska Medical Center, Omaha, 68198, Nebraska, USA

    Adam R. Karpf

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Balch, C., Nephew, K.P. (2013). Epigenetic Targeting Therapies to Overcome Chemotherapy Resistance. In: Karpf, A. (eds) Epigenetic Alterations in Oncogenesis. Advances in Experimental Medicine and Biology, vol 754. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9967-2_14

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