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Innate Immune Regulation and Cancer Immunotherapy pp 89–119Cite as

Dendritic Cell Subsets and Immune Regulation

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Abstract

Dendritic cells (DC) are efficient antigen presenting cells. They represent a dynamic network in the immune system and can collect and process antigens for presentation to T cells. Although all can present antigens, DC differ in the additional regulatory signals they transmit to direct T cells to different types of immune responses or to tolerance. Many DC subtypes are present in non-lymphoid and lymphoid tissues and their development and function is modulated by exogenous factors such as cytokines and microbial products. Many studies on DC biology in recent years have revealed their important roles in modulating immune responses, which provide great potential for designing more effective vaccines and new therapies for the treatment of cancer and other immune-related diseases through targeting the DC.

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  1. Centre for Immunology, Burnet Institute, 85 Commercial Road, Melbourne, VIC, 3004, Australia

    Meredith O’Keeffe

  2. The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, VIC, 3052, Australia

    Mireille H. Lahoud, Irina Caminschi & Li Wu

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  1. Meredith O’Keeffe
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  1. Center for Cell & Gene Therapy, Baylor College of Medicine, Baylor Plaza 1, Houston, 77030, Texas, USA

    Rongfu Wang

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O’Keeffe, M., Lahoud, M.H., Caminschi, I., Wu, L. (2012). Dendritic Cell Subsets and Immune Regulation. In: Wang, R. (eds) Innate Immune Regulation and Cancer Immunotherapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9914-6_7

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