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Innate Immune Regulation and Cancer Immunotherapy pp 319–334Cite as

Myeloid-Derived Suppressor Cells in Cancer: Mechanisms and Therapeutic Perspectives

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Abstract

Patients with cancer have an impaired T cell response that can decrease the potential therapeutic benefit of cancer vaccines and other forms of immunotherapy. l-Arginine (l-Arg) is a nonessential amino acid that is fundamental for the function of T lymphocytes. Recent findings in tumor-bearing mice and cancer patients indicate that the increased metabolism of l-Arg by myeloid-derived suppressor cells (MDSC) producing Arginase I inhibits T lymphocyte responses. Here, we discuss some of the most recent concepts of how MDSC expressing Arginase I may regulate T cell function in cancer and other chronic inflammatory diseases, and suggest possible therapeutic interventions to overcome this inhibitory effect.

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Acknowledgments

This work was supported by NIH/NCI Grants 5R01CA082689, 5R01CA107974 and 5P20RR021970

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  1. Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    Paulo C. Rodríguez

  2. Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    Paulo C. Rodríguez & Augusto C. Ochoa

  3. Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    Augusto C. Ochoa

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  1. Paulo C. Rodríguez
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  2. Augusto C. Ochoa
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Correspondence to Augusto C. Ochoa .

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  1. Center for Cell & Gene Therapy, Baylor College of Medicine, Baylor Plaza 1, Houston, 77030, Texas, USA

    Rongfu Wang

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© 2012 Springer Science+Business Media, LLC

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Rodríguez, P.C., Ochoa, A.C. (2012). Myeloid-Derived Suppressor Cells in Cancer: Mechanisms and Therapeutic Perspectives. In: Wang, R. (eds) Innate Immune Regulation and Cancer Immunotherapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9914-6_18

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