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Innate Immune Regulation and Cancer Immunotherapy pp 267–287Cite as

Negative Regulators of NF-κB Activation and Type I Interferon Pathways

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Abstract

The transcription factor NF-κB and type I interferon (IFN) are both important modulators of the innate immune system. NF-κB plays a key role in the up-regulation of pro-inflammatory cytokines, adhesion molecules and chemokines (Oncogene 25:6758–6780, 2006), whereas type I IFN is essential for the initiation of an antiviral state in cells, and for the detection of malignant cells (Microbes Infect 4(6):647–655, 2002).

This chapter summarizes the inhibitory mechanisms both endogenous and from pathogens that target NF-κB and the type I IFN system. Without internal regulatory systems, deregulated NF-κB and type I IFN can cause inflammatory diseases and malignancy in cells. Pathogens also target both signalling systems to replicate within the host.

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  1. School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    Caroline Murphy & Luke A. J. O’Neill

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  1. Caroline Murphy
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  2. Luke A. J. O’Neill
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Correspondence to Caroline Murphy .

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  1. Center for Cell & Gene Therapy, Baylor College of Medicine, Baylor Plaza 1, Houston, 77030, Texas, USA

    Rongfu Wang

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Murphy, C., O’Neill, L.A.J. (2012). Negative Regulators of NF-κB Activation and Type I Interferon Pathways. In: Wang, R. (eds) Innate Immune Regulation and Cancer Immunotherapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9914-6_15

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