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Imaging Pulmonary Drug Delivery

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Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

This chapter focuses on the current practices of gamma imaging for the ­purposes of quantification of lung deposition or lung dose of inhaled therapeutics. The chapter reviews the various methodologies required for a viable imaging study. Specifically, a brief background on gamma imaging, radiolabeling method development and validation, dose administration, image acquisition, and image analysis is presented.

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References

  1. Adams WP et al (2010) Demonstrating bioequivalence of locally acting orally inhaled drug products (OIPs): workshop summary report. J Aerosol Med 23(1):1–29

    CAS  Google Scholar 

  2. Bailey DL (2006) Imaging the airways in 2006. J Aerosol Med 19(1):1–7

    Article  PubMed  Google Scholar 

  3. Cheng YS, Irshad H, Kuehl P, Holmes TD, Sherwood R, Hobbs CH (2008) Lung deposition of droplet aerosol in monkeys. Inhalation Tox 20:1029–1039

    Article  CAS  Google Scholar 

  4. Clark AR, Borgstrom L (2002) In vitro testing of pharmaceutical aerosols and predicting lung deposition from in vitro measurements. In: Bisgaard H, O’Callaghan C, Smaldone GC (eds) Drug delivery to the lung. Marcel Dekker, New York, pp 105–142

    Google Scholar 

  5. Conway JH, Walker P, Fleming JS, Bondesson E, Borgstrom L, Holgate ST (2000) ­Three-dimensional description of the deposition of inhaled terbutaline sulphate administered via turbuhaler. In: Dalby RN, Byron PR, Farr SJ, Peart J (eds) Respiratory drug delivery VII. Serentec Press, Raleigh, pp 607–609

    Google Scholar 

  6. Daley-Yates PT (2010) The clinical utility of pharmacokinetics in demonstrating bioequivalence of locally acting orally inhaled drugs. In: Dalby RN, Byron PR, Peart J (eds) Respiratory drug delivery 2010. Davis Healthcare International, River Grove, pp 273–284

    Google Scholar 

  7. De Backer W, Devolder A, Poli G, Acerbi D, Monno R, Herpich C, Sommerer K, Meyer T, Mariotti F (2010) Lung deposition of BDP/formoterol HFA pMDI in healthy volunteers, ­asthmatics and COPD patients. J Aerosol Med 23(3):137–148

    Google Scholar 

  8. Dolovich M, Rhem R, Rashid F, Coates G, Hill M, Bowen B (1996) Measurement of the ­particle size and dosing characteristics of a radiolabeled albuterol sulphate lactose blend used in the spiros dry powder inhaler. In: Dalby RN, Byron PR, Farr SJ, Peart J (eds) Respiratory drug delivery V. Interpharm Press, Buffalo Grove, pp 332–335

    Google Scholar 

  9. Farr SJ (1996) The physico-chemical basis of radiolabeling metered dose inhalers with 99mTc. J Aerosol Med 9(S1):S27–S36

    Article  PubMed  Google Scholar 

  10. Fleming JS, Hashish AH, Conway JH, Hartley-Davies R, Nassim MA, Guy MJ, Coupe J, Holgate ST, Moore E, Bailey AG, Martonen TB (1997) A technique for simulating radionuclide images from the aerosol deposition pattern in the airway tree. J Aerosol Med 10(3):199–212

    Article  Google Scholar 

  11. Fleming JS, Epps BP, Conway JH, Martonen TB (2006) Comparison of SPECT aerosol ­deposition data with a human respiratory tract model. J Aerosol Med 19(3):268–278

    Article  PubMed  Google Scholar 

  12. Leach CL, Davidson PJ, Hasselquist BE, Boudreau RJ (2002) Lung deposition of ­hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: a cross-over study in healthy volunteers. Chest 122:510–516

    Article  PubMed  CAS  Google Scholar 

  13. Leach CL, Colice GL, Luskin A (2009) Particle size of inhaled corticosteroids: does it matter? J Allergy Clin Immunol 124(6):S88–S93

    Article  PubMed  CAS  Google Scholar 

  14. Lee Z, Berridge MS, Nelson AD, Heald DL (2001) The effect of scatter and attenuation on aerosol deposition as determined by gamma scintigraphy. J Aerosol Med 14:167–183

    Article  PubMed  CAS  Google Scholar 

  15. McDonald JD, Kuehl P, Norenberg JP, Gershman B, Anderson TL (2009) Effect of particle size on the regional deposition of inhaled technitium-99m labeled particles in rodents. Am J Respir Crit Care Med 179:A5034

    Google Scholar 

  16. Moller W, Felten K, Meyer G, Meyer P, Seitz J, Kreyling WG (2009) Correction in dose assessment of 99mT radiolabeled aerosol particle targeted to central human airways using planar gamma camera imaging. J Aerosol Med 22(1):45–54

    Google Scholar 

  17. Newman SP (2009) In vivo assessment. In: Newman S (ed) Respiratory drug delivery: ­essential theory and practice. Davis Healthcare International, River Grove, pp 97–134

    Google Scholar 

  18. Newman SP, Pitcairn GR (2006) Gamma scintigraphy and SPECT. In: Lappin G, Temple S (eds) Radiotracers in drug development. Taylor and Francis, Boca Raton, pp 269–288

    Chapter  Google Scholar 

  19. Newman SP, Moren F, Trofast E, Talaee N, Clarke SW (1989) Deposition and clinical efficacy of terbutaline sulphate from turbuhaler, a new multidose powder inhaler. Eur Respir J 2(3):247–252

    PubMed  CAS  Google Scholar 

  20. O’Connor DK (2010) Role of pharmacokinetics in establishing bioequivalence for orally inhaled drug products. In: Dalby RN, Byron PR, Peart J (eds) Respiratory drug delivery 2010. Davis Healthcare International, River Grove, pp 245–247

    Google Scholar 

  21. Pitcairn GR, Newman SP (1997) Tissue attenuation corrections in gamma scintigraphy. J Aerosol Med 10:187–198

    Article  Google Scholar 

  22. Smaldone GC (2001) Radionuclide scanning, respiratory physiology and pharmacokinetics. J Aerosol Med 14:135–137

    Article  PubMed  CAS  Google Scholar 

  23. Smaldone GC, Walser L, Perry RJ, Ilowite JS, Bennett WD, Greco M (1989) Generation and administration of aerosol for medical and physiological research studies. J Aerosol Med 2(2):81–87

    Article  Google Scholar 

  24. Thiel CG (1998) Can in vitro particle size measurements be used to predict pulmonary ­deposition of aerosol from inhalers? J Aerosol Med 11(S1):S43–S51

    PubMed  Google Scholar 

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Correspondence to Philip J. Kuehl .

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© 2011 Controlled Release Society

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Kuehl, P.J. (2011). Imaging Pulmonary Drug Delivery. In: Smyth, H., Hickey, A. (eds) Controlled Pulmonary Drug Delivery. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9745-6_20

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