Abstract
One method by which to modify the release rate of a drug in the pulmonary tract, is through the use of polymeric systems. There are several natural and synthetic polymers that have been studied in vitro or in vivo in animals to assess pulmonary drug delivery and sustained release. This chapter focuses on some of the more common non-conjugated polymers utilized for inhalation drug delivery and draws examples from an array of pre-clinical findings.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Adi H, Young PM, Chan H, Salama R, Traini D (2010) Controlled release antibiotics for dry powder lung delivery. Drug Dev Ind Pharm 36:119–126
Alhusban FA, Seville PC (2009) Carbomer-modified spray-dried respirable powders for pulmonary delivery of salbutamol sulfate. J Microencapsul 26:444–455
Amecke B, Bendix D, Entenmann G (1992) Resorbable polyesters: composition, properties, and applications. Clin Mater 10:47–50
Arnold MM, Gorman EM, Schieber LJ, Munson EJ, Berkland C (2007) NanoCipro encapsulation in monodisperse large porous PLGA microparticle. J Control Release 121:100–109
Bailey MM, Berkland CJ (2009) Nanoparticle formulations in pulmonary drug delivery. Med Res Rev 29:196–212
Brannon-Peppas L (1997) Polymers in controlled drug delivery. Med Plast Biomater 4:34–44
Cook RO, Pannu RK, Kellaway IW (2005) Novel sustained release microspheres for pulmonary drug delivery. J Control Release 104:79–90
Coowanitwong I, Arya V, Kulvanich P, Hochhaus G (2008) Slow release formulations of inhaled rifampin. AAPS J 10:342–348
Courrier HM, Butz N, Vandamme TF (2002) Pulmonary drug delivery systems: recent development and prospectives. Crit Rev Therap Drug Carrier Syst 19:425–498
Donovan M, McGill S, Smyth H (2008) Swellable particles for sustained release drug delivery to the lungs. Respir Drug Deliv 3:857–860
Edwards DA, Ben-Jebria A, Langer R (1998) Recent advances in pulmonary drug delivery using large, porous inhaled particles. J Appl Physiol 85:379–385
Edwards DA, Hanes J, Caponetti G, Hrkach K, Ben-Jebria A, Eskew ML, Mintzes J, Deaver D, Lotan N, Langer R (1997) Large porous particles for pulmonary drug delivery. Science 276:1868–1871
El-Baseir MM, Kellaway IW (1998) Poly(L-lactic acid) microspheres for pulmonary drug delivery: release kinetics and aerosolization studies. Int J Pharm 175:135–145
Fu J, Fiegel J, Hanes J (2004) Synthesis and characterization of PEG-based ether anhydride terpolymers: novel polymers for controlled drug release. Macromolecules 37:7174–7180
Fu J, Fiegel J, Krauland E, Hanes J (2002) New polymeric carriers for controlled drug delivery following inhalation or injection. Biomaterials 23:4425–4433
Garcia-Contreras L, Morçöl T, Bell SJD, Hickey AJ (2003) Evaluation of novel particles as pulmonary delivery systems for insulin in rats. AAPS Pharm Sci 5(2):article 9
Hickey AJ, Suarez S, Bhat M, O’Hara P, Lalor CB, Atkins K, Hopfer R, McMurry DN (1998) Efficacy of rifampicin-poly(lactide-co-glycolide) microspheres in treating tuberculosis. Respir Drug Deliv VI 1:201–209
Jaspart S, Bertholet P, Piel G, Dogné J, Delattre L, Evrard B (2007) Solid lipid microparticles as a sustained release system for pulmonary drug delivery. Eur J Pharm Biopharm 65:47–56
Kawashima Y, Yamamoto H, Takeuchi H, Fujioka S, Hino T (1999) Pulmonary delivery of insulin with nebulized DL-lactide/glycolide copolymer (PLGA) nanospheres to prolong hypoglycemic effect. J Control Release 62:279–287
Koushik K, Dhanda DS, Cheruvu NPS, Kompella UB (2004) Pulmonary delivery of deslorelin: large-porous PLGA particles and HPβCD complexes. Pharm Res 21:1119–1126
Leach CL, Mameister WM, Tomai MA, Hammerbeck DM, Stefely JS (2000) Oligolactic acid (OLA) biomatricies for sustained release of asthma therapeutics. Respir Drug Deliv VII 2:291–294
Learoyd TP, Burrows JL, French E, Seville PC (2006) Leucine-modified PLGA-based respirable spray-dried powders for sustained drug delivery. Respir Drug Deliv 2:437–440
Learoyd TP, Burrows JL, French E, Seville PC (2006) Sustained drug delivery from chitosan-based respirable spray-dried powders. Respir Drug Deliv 2:441–443
Learoyd TP, Burrows JL, French E, Seville PC (2008) Chitosan-based spray-dried respirable powders for sustained delivery of terbutaline sulfate. Eur J Pharm Biopharm 68:224–234
Learoyd TP, Burrows JL, French E, Seville PC (2009) Sustained delivery by leucine modified chitosan spray-dried respirable powders. Int J Pharm 372:97–104
Li FQ, Hu JH, Lu B, Yao H, Zhang WG (2001) Ciprofloxacin-loaded bovine serum albumin microspheres: Preparation and drug-release in vitro. J Microencapsul 18:825–829
Li Z, Stefely JS (2004) Aerosol sustained release formulations with oligolactic acid (OLA). Respir Drug Deliv IX 2:321–324
Louey MD, Garcia-Contreras L (2004) Controlled release products for respiratory delivery. Am Pharm Rev 7:82–87
Lu B, Zhang Q, Yang H (2003) Lung-targeting microspheres of carboplatin. Int J Pharm 265:1–11
Lu D, Garcia-Contreras L, Xu D, Kurtz SL, Liu J, Braunstein M, McMurray DN, Hickey AJ (2007) Poly (lactide-c-glycolide) microspheres in respirable sizes enhance an in vitro T cell response to Mycobacterium tuberculosis antigen 85B. Pharm Res 24:1834–1843
Morimoto K, Katsumata H, Yabuta T, Iwanaga K, Kakemi M, Tabata Y, Ikada Y (2002) Gelatin microsphere as a pulmonary delivery system: evaluation of salmon calcitonin absorption. J Pharm Pharmacol 52:611–617
Morimoto K, Metsugi K, Katsumata H, Iwanaga K, Kakemi M (2001) Effects of low-viscosity sodium hyaluronate preparation on pulmonary absorption of rh-insulin in rats. Drug Dev Ind Pharm 27:365–371
Mu L, Feng SS (2001) Fabrication, characterization and in vitro release of paclitaxel (Taxol®) loaded poly (lactic-co-glycolic acid) microspheres prepared by pray drying technique with lipid/cholesterol emulsifiers. J Control Release 76:239–254
Müller RH, Maaβen S, Wayhers H, Specht F, Lucks JS (1996) Cyctotoxcity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles. Int J Pharm 138:85–94
Nah J, Jeong Y, Cho C, Kim S (2000) Drug-delivery system based on core-shell type nanoparticles composed of poly(γ-benzyl-L-glutamate) and poly(ethylene oxide). J Appl Polym Sci 75:1115–1126
Naikwade S, Bajaj A (2009) Preparation and in vitro evaluation of budesonide spray dried microparticles for pulmonary delivery. Sci Pharm 77:419–441
Oyarzun-Ampuero FA, Brea J, Loza MI, Torres D, Alonso MJ (2009) Chitosan hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma. Int J Pharm 381:122–129
Pulapura S, Kohn J (1992) Trends in the development of bioresorbable polymers for medical applications. J Biomater Appl 6:215–250
Rouse JJ, Whateley TL, Thomas M, Ecclecston GM (2007) Controlled drug delivery to the lungs: Influence of hyaluronic acid solution conformation on its adsorption to hydrophobic drug particles. Int J Pharm 330:175–182
Ruan G, Feng S (2003) Preparation and characterization of poly(lactic acid) poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) microspheres for controlled release of paclitaxel. Biomaterials 24:5037–5044
Salama RO, Traini D, Chan H, Sung A, Ammit AJ, Young PM (2009) Preparation and evaluation of controlled release microparticles for respiratory protein therapy. J Pharm Sci 98:2709–2717
Salama R, Traini D, Chan H, Young PM (2009) Recent advances in controlled release pulmonary therapy. Curr Drug Deliv 6:404–414
Salama RO, Traini D, Chan H, Young PM (2008) Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. Eur J Pharm Biopharm 70:145–152
Schliecker G, Schmidt G, Fusch S, Wombacher R, Kissel T (2003) Hydrolytic degradation of poly(lactide-co-glycolide) films: effect of oligomers on degradation rate and crystallinity. Int J Pharm 266:39–49
Shi S, Hickey AJ (2010) PLGA microparticles in respirable sizes enhance an in vitro T cell response to recombinant Mycobacterium tuberculosis antigen TB10.4-Ag58B. Pharm Res 27:350–360
Shoyele SA (2008) Controlling the release of proteins/peptides via the pulmonary route. Drug Deliv Syst 437:141–148
Suarez S, O’Hara P, Kazantseva M, Newcomer CE, Hopfer R, McMurray DN, Hickey AJ (2001) Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: screening in an infectious disease model. Pharm Res 18:1315–1319
Sung JC, Pulliam BL, Edwards DA (2007) Nanoparticles for drug delivery to the lungs. Trends Biotechnol 25:563–570
Sung JC, Padilla DJ, Garcia-Contreras L, VerBerkmoes JL, Durbin D, Peloquin CA, Elbert KJ, Hickey AJ, Edwards DA (2009) Formulation and pharmacokinetics of self-assembled rifampicin nanoparticle systems for pulmonary delivery. Pharm Res 26:1847–1855
Surendrakumar K, Martyn GP, Hodgers ECM, Jansen M, Blair JA (2003) Sustained release of insulin from sodium hyaluronate based dry powder formulations after pulmonary delivery of beagle dogs. J Control Release 91:385–394
Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y (2009) Improved cellular update of chitosan-modified PLGA nanospheres by A549 cells. Int J Pharm 382:198–204
Takeuchi H, Yamamoto H, Kawashima Y (2001) Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv Drug Deliv Rev 47:39–54
Tomoda K, Ohkoshi T, Hirota K, Sonavane GS, Nakajima T, Terada H, Komuro M, Kitazota K, Makino K (2009) Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer. Colloids Surf B Biointerfaces 17:177–182
Wang C, Muttil P, Lu D, Beltran-Torres AA, Garcia-Contreras L, Hickey AJ (2009) Screening for potential adjuvants administered by the pulmonary route for tuberculosis vaccines. AAPS J 11:139147
Wischke C, Schwendeman SP (2008) Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. Int J Pharm 364:298–327
Wu L, da Rocha SRP (2007) Biocompatible and biodegradable copolymer stabilizers for hydrofluoroalkane dispersions: a colloidal probe microscopy investigation. Langmuir 23:12104–12110
Yamada K, Kamada N, Odomi M, Okada N, Nabe T, Fujita T, Kohno S, Yamamoto A (2005) Carrageenans can regulate the pulmonary absorption of antiasthmatic drugs and their retention in the rat lung tissues without any membrane damage. Int J Pharm 293:63–72
Yamada K (2007) Control of pulmonary absorption of drugs by various pharmaceutical excipients. Yakugaku Zasshi 127:631–641
Yamamoto H, Kuno Y, Sugimoto S, Takeuchi H, Kawashima Y (2005) Surface modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin in mucoadhesion and opening of the intracellular tight space. J Control Release 102:373–381
Yang Y, Bajaj N, Xu P, Ohn K, Tsifansky MD, Yeo Y (2009) Development of highly porous large PLGA microparticles for pulmonary drug delivery. Biomaterials 30:1947–1953
Zhang Q, Shen Z, Nagai T (2001) Prolonged hypoglycemic effect of insulin-loaded polybutylcyanoacrylate nanoparticles after pulmonary administration to normal rats. Int J Pharm 218:75–80
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Controlled Release Society
About this chapter
Cite this chapter
Sheth, P., Myrdal, P.B. (2011). Polymers for Pulmonary Drug Delivery. In: Smyth, H., Hickey, A. (eds) Controlled Pulmonary Drug Delivery. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9745-6_12
Download citation
DOI: https://doi.org/10.1007/978-1-4419-9745-6_12
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-9744-9
Online ISBN: 978-1-4419-9745-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)