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Protein Aggregation and Multiple Organelle Damage After Brain Ischemia

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Translational Stroke Research

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

Protein aggregation leads to a broad range of conformational diseases. Protein folding during synthesis and assembly to subcellular structures require cooperation of several sophisticated ATP-dependent cellular systems including protein chaperoning, protein trafficking, protein assembling, as well as protein degradation. Emerging evidence strongly suggests that brain ischemia leads to dysfunction of these ATP-dependent protein assembly and quality control systems, resulting in protein misfolding, ubiquitination, and aggregation during the postischemic phase. Misfolded proteins are aggregated with subcellular organelles and eventually damage these organelles, leading to multiple organelle failure and delayed neuronal death after brain ischemia. In this chapter, we will first review the provenance and history of protein aggregation in the brain ischemic field and then update latest concept and mechanisms of protein aggregation and multiple organelle damage after brain ischemia.

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Abbreviations

EPTA:

Ethanolic phosphotungstic acid

Ubi-proteins:

Ubiquitin-conjugated proteins

DG:

Dentate gyrus

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Authors and Affiliations

  1. Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA

    Chunli H. Liu MD, Fan Zhang PhD, Tibor Krisrian PhD, Brian Polster PhD, Gary M. Fiskum PhD & Bingren Hu PhD

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  1. Chunli H. Liu MD
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  2. Fan Zhang PhD
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  3. Tibor Krisrian PhD
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  4. Brian Polster PhD
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  6. Bingren Hu PhD
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Correspondence to Bingren Hu PhD .

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Editors and Affiliations

  1. , Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA

    Paul A. Lapchak

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Liu, C.H., Zhang, F., Krisrian, T., Polster, B., Fiskum, G.M., Hu, B. (2012). Protein Aggregation and Multiple Organelle Damage After Brain Ischemia. In: Lapchak, P., Zhang, J. (eds) Translational Stroke Research. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9530-8_5

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