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Heart Mitochondria: A Receiver and Integrator of Signals

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Book cover Signaling in the Heart

Abstract

Besides their essential bioenergetic role in supplying ATP, heart mitochondria play a central role in the regulatory and signaling events that occur in response to physiological stresses, including but not limited to heart failure (HF), myocardial ischemia and reperfusion (I/R), hypoxia, oxidative stress (OS), and hormonal and cytokine stimuli. Research on both intact cardiac and skeletal muscle tissue and cultured cardiomyocytes has just begun to probe the nature and the extent of mitochondrial involvement in interorganelle communication, hypertrophic growth, and cell death. In this chapter, we examine heart mitochondria under the perspective of a receiver/integrator and transmitter of signals, dissecting the multiple and interrelated signaling pathways playing at both the molecular and biochemical levels with particular focus on nuclear and cytoplasmic factors involved in the shaping of the organelles’ responses, and gauging the effect that mitochondria have (as a receiver, integrator, and transmitter of signals) on cardiac phenotype.

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Marín-García, J. (2011). Heart Mitochondria: A Receiver and Integrator of Signals. In: Signaling in the Heart. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9461-5_8

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