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Signaling in the Heart pp 247–256Cite as

Signaling in Endomyocarditis

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Abstract

Myocarditis is an inflammatory disorder of the myocardium that is associated with cardiac dysfunction. Many viruses have been implicated as causes of myocarditis, most commonly adenoviruses and enteroviruses, such as the coxsackieviruses. Viral myocarditis has been recognized as a cause of congestive heart failure (HF).

Endocarditis is an infection of the endocardium that may involve cardiac valves and adjacent structures and may be caused by wide spectrum of bacteria and fungi. In this chapter, we focus on the host cell-signaling systems which are involved in the different phases of viral and/or bacterial infection, including viral entry into the cell and the development of innate immunity and in a number of signaling molecules (both host and pathogen originated) that are involved in different aspects of pathogenesis of myocarditis/infective endocarditis. Also signaling pathways participating in the activation of adaptive immunity toward the viral/bacteria pathogen is presented.

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  1. The Molecular Cardiology and Neuromuscular Institute, Raritan Avenue 75, 08904, Highland Park, NJ, USA

    José Marín-García M.D. (Director)

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  1. José Marín-García M.D.
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Correspondence to José Marín-García M.D. .

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Marín-García, J. (2011). Signaling in Endomyocarditis. In: Signaling in the Heart. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9461-5_12

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  • DOI: https://doi.org/10.1007/978-1-4419-9461-5_12

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