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Extracellular Ca2+-Sensing Receptor and Kidney Function

  • Chapter
Calcium-Sensing Receptor

Part of the book series: Endocrine updates ((ENDO,volume 19))

Abstract

Changes in extracellular calcium concentration (Ca2+ o) dramatically affect many aspects of kidney function under both basal and hormone-stimulated conditions. Normally about 60% of the plasma calcium (100% of the ionized calcium) is filtered through the glomerular capillaries and is reabsorbed virtually along the entire nephron, with the exception of the thin descending and ascending limbs of Henle’s loop (1,2). Sixty-five percent of the Ca2+ filtered at the glomerulus is usually reabsorbed in the proximal tubule (PT) with the remaining Ca2+ reabsorbed by the thick ascending limb of Henle’s loop (TAL) and more distal nephron segments (see figure 1 A). Sodium and calcium transport by the kidney generally occur in parallel such that there is a codependence of calcium and sodium transport (3).

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Authors and Affiliations

  1. School of Biological Sciences, University of Manchester, UK

    Daniela Riccardi Ph.D.

  2. Yale University School of Medicine New Haven, CT, USA

    Steven C. Hebert M.D.

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  1. Daniela Riccardi Ph.D.
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  2. Steven C. Hebert M.D.
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Editors and Affiliations

  1. Endocrine-Hypertension Division Department of Medicine, Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts, USA

    Naibedya Chattopadhyay  & Edward M. Brown  & 

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Riccardi, D., Hebert, S.C. (2003). Extracellular Ca2+-Sensing Receptor and Kidney Function. In: Chattopadhyay, N., Brown, E.M. (eds) Calcium-Sensing Receptor. Endocrine updates, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9256-7_4

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  • DOI: https://doi.org/10.1007/978-1-4419-9256-7_4

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