Skip to main content
SpringerLink
Log in

Expression and Functions of Calcium-Sensing Receptor in the Central Nervous System

  • Chapter
Book cover Calcium-Sensing Receptor

Part of the book series: Endocrine updates ((ENDO,volume 19))

  • 129 Accesses

Abstract

Calcium is the premier messenger molecule mediating adaptive changes in neuroarchitecture in response to signals such as neurotransmitters and neurotrophic factors. Calcium is also involved in long-term adaptive processes, such as memory. Such adaptive changes within an optimal range of intracellular Ca2+ (Ca2+ i) play major roles during development and adult plasticity of the nervous system (1,2). However, when Ca2+ i rises too high and/or for too long a time-period, maladaptive degradation of cellular components can occur. The source of the messenger calcium is either the pool of extracellular Ca2+ ions or calcium sequestered within intracellular pools, such as the endoplasmic reticulum (ER) and mitochondria, or so-called calciosomes (the site for calcium-triggered calcium release) (3). In the former instance calcium homeostasis in the CNS is maintained by Ca2+ entry into neural cells by voltage-sensitive or ligand-gated calcium channels and Ca2+ release from the ER or calciosomes in case of the latter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Schiegg, A, Gerstner W, Ritz R, van Hemmen JL 1995 Intracellular Ca2+ stores can account for the time course of LTP induction: A model of Ca2+ dynamics in dendritic spines. J Neurophysiol 74:1046–1055

    PubMed  CAS  Google Scholar 

  2. Toescu EC, Verkhratsky A 2000 Parameters of calcium homeostasis in normal neuronal ageing. J Anat 197:563–569

    Article  PubMed  CAS  Google Scholar 

  3. Brown EM, Vassilev PM, Hebert SC 1995 Calcium ions as extracellular messengers. Cell 83:679–682.

    Article  PubMed  CAS  Google Scholar 

  4. Heinemann U, Lux HD, Gutnick MJ 1977 Extracellular free calcium and potassium during paroxysmal activity in cerebral cortex of the rat. Exp Brain Res 27:237–243

    Article  PubMed  CAS  Google Scholar 

  5. Zador A, Koch C 1994 Linearized models of calcium dynamics: Formal equivalence to the cable equation. J Neurosci 14:4705–4715

    PubMed  CAS  Google Scholar 

  6. Dudek SM, Baer MF 1992 Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. Proc Natl Acad Sci USA 89:4363–4367

    Article  PubMed  CAS  Google Scholar 

  7. Bliss TVP, Collingridge GL 1993 A synaptic model of memory: Longterm potentiation in the hippocampus. Nature 361: 31–39

    Article  PubMed  CAS  Google Scholar 

  8. MacLeod RJ, Brown EM 2001 Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81:239–297

    PubMed  Google Scholar 

  9. Brown EM, Gamba G, Riccardi D, Lombardi D, Butters R, Kifor O, Sun A, Hediger MA, Lytton J, Hebert SC 1993 Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature 366:575–580

    Article  PubMed  CAS  Google Scholar 

  10. Ruat M, Molliver ME, Snowman AM, Snyder SH 1995 Calcium-sensing receptor: Molecular cloning from rat striatal library and localization to nerve terminals. Proc Natl Acad Sci USA 92:3161–3165

    Article  PubMed  CAS  Google Scholar 

  11. Rogers KV, Dunn CK, Hebert SC, Brown EM 1997 Localization of calcium receptor mRNA in the adult rat central nervous system by in situ hybridization. Brain Res 744:47–56

    Article  PubMed  CAS  Google Scholar 

  12. Brown EM, Hebert SC 1995 A cloned Ca2+-sensing receptor: a mediator of direct effects of extracellular Ca2+ on renal function? J Am Soc Nephrol 6:1530–1540

    PubMed  CAS  Google Scholar 

  13. Washburn DL, Anderson JW, Ferguson AV 2000 The calcium receptor modulates the hyperpolarization-activated current in subfornical organ neurons. Neuroreport 11:3231–3235

    Article  PubMed  CAS  Google Scholar 

  14. Washburn DL, Smith PM, Ferguson AV 1999 Control of neuronal excitability by an ion-sensing receptor. Eur J Neurosci 11:1947–1954

    Article  PubMed  CAS  Google Scholar 

  15. Washburn DL, Anderson JW, Ferguson AV 2000 A subthreshold persistent sodium current mediates bursting in rat subfornical organ neurones. J Physiol 529:359–371

    Article  PubMed  CAS  Google Scholar 

  16. Leshem M, Del Canho S, Schulkin J 1999 Calcium hunger in the parathyroidectomized rat is specific. Physiol Behav 67:555–559

    Article  PubMed  CAS  Google Scholar 

  17. Schwanzel-Fukuda M 1999 Origin and migration of luteinizing hormone-releasing hormone neurons in mammals. Microsc Res Tech 44:2–10

    Article  PubMed  CAS  Google Scholar 

  18. Ye C, Ho-Pao CL, Kanazirska M, Quinn S, Seidman CE, Seidman JG, Brown EM, Vassilev PM 1997 Deficient cation channel regulation in neurons from mice with targeted disruption of the extracellular Ca2+-sensing receptor gene. Brain Res Bull 44:75–84

    Article  PubMed  CAS  Google Scholar 

  19. Ye C, Rogers K, Bai M, Quinn SJ, Brown EM, Vassilev PM 1996 Agonists of the Ca2+-sensing receptor (CaR) activate nonselective cation channels in HEK293 cells stably transfected with the human CaR. Biochem Biophys Res Commun 226:572–579

    Article  PubMed  CAS  Google Scholar 

  20. Vassilev PMYe C, Kanazirska M, Quinn S, Brown EM, Vassilev PM 1996 Modulation by polycationic Ca2+-sensing receptor agonists of nonselective cation channels in rat hippocampal neurons. Biochem Biophys Res Commun 224:271–280

    Article  PubMed  CAS  Google Scholar 

  21. Vassilev PM, Ho-Pao CL, Kanazirska MP, Ye C, Hong K, Seidman CE, Seidman JG, Brown EM 1997 Ca2+-sensing receptor (CaR)-mediated activation of K+ channels is blunted in CaR gene-deficient mouse neurons. Neuroreport 8:1411–1416

    Article  PubMed  CAS  Google Scholar 

  22. Vassilev PM, Mitchel J, Vassilev M, Kanazirska M, Brown EM 1997 Assessment of frequency-dependent alterations in the level of extracellular Ca2+ in the synaptic cleft. Biophys J 72:2103–2116

    Article  PubMed  CAS  Google Scholar 

  23. Koch, C, Zador A 1993 The function of dendritic spines: Devices subserving biochemical rather than electrical compartmentalization. J Neurosci 13:413–422

    PubMed  CAS  Google Scholar 

  24. Zador A, Koch C, Brown TH 1990 Biophysical model of a Hebbian synapse. Proc Natl Acad Sci USA 87:6718–6722

    Article  PubMed  CAS  Google Scholar 

  25. Ye C, Ho-Pao CL, Kanazirska M, Quinn S, Rogers K, Seidman CE, Seidman JG, Brown EM, Vassilev PM 1997 Amyloid-beta proteins activate Ca2+-permeable channels through calcium-sensing receptors. J Neurosci Res 47:547–554

    Article  PubMed  CAS  Google Scholar 

  26. Chattopadhyay N, Ye CP, Yamaguehi T, Kifor O, Vassilev PM, Nishimura R, Brown EM 1998 Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel. Glia 24:449–458

    Article  PubMed  CAS  Google Scholar 

  27. Chattopadhyay N, Ye C, Yamaguehi T, Nakai M, Kifor O, Vassilev PM, Nishimura RN, Brown EM 1999 The extracellular calcium-sensing receptor is expressed in rat microglia and modulates an outward K+ channel. J Neurochem 72:1915–1922

    Article  PubMed  CAS  Google Scholar 

  28. Chattopadhyay N, Evliyaoglu C, Heese O, Carroll R, Sanders J, Black P, Brown EM 2000 Regulation of secretion of PTHrP by Ca2+-sensing receptor in human astrocytes, astrocytomas, and meningiomas. Am J Physiol Cell Physiol 279:C691–C699

    PubMed  CAS  Google Scholar 

  29. Chattopadhyay N, Ye CP, Yamaguchi T, Vassilev PM, Brown EM 1999 Evidence for extracellular calcium-sensing receptor mediated opening of an outward K+ channel in a human astrocytoma cell line (U87). Glia 26:64–72

    Article  PubMed  CAS  Google Scholar 

  30. Chattopadhyay N, Ye CP, Yamaguehi T, Kerner R, Vassilev PM, Brown EM 1999 Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells. Brain Res 851:116–124

    Article  PubMed  CAS  Google Scholar 

  31. Ferry S, Traiffort E, Stinnakre J, Ruat M 2000 Developmental and adult expression of rat calcium-sensing receptor transcripts in neurons and oligodendrocytes. Eur J Neurosci 12:872–884

    Article  PubMed  CAS  Google Scholar 

  32. Chiu SY, Wilson GF 1989 The role of potassium channels in Schawnn cell proliferation in Wallerian degenration of explant rabbit sciatic nerves. J Physiol 408:199–222

    PubMed  CAS  Google Scholar 

  33. Allard J, Barron S, Diaz J, Lubetzki C, Zalc B, Schwartz JC, Sokoloff P 1998 A rat G protein-coupled receptor selectively expressed in myelin-forming cells. Eur J Neurosci 10:1045–1053

    Article  PubMed  CAS  Google Scholar 

  34. An S, Bleu T, Zheng Y, Goetzl E J 1998 Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. Mol Pharmacol 54:881–888

    PubMed  CAS  Google Scholar 

  35. Walz W, Wilson DC 1986 Calcium entry into cultured mouse astrocytes. Neurosci Lett 67:301–306

    Article  PubMed  CAS  Google Scholar 

  36. Zanotti S, Charles A 1997. Extracellular calcium sensing by glial cells: low extracellular calcium induces intracellular calcium release and intercellular signaling. J Neurochem 69:594–602.

    Article  PubMed  CAS  Google Scholar 

  37. Newman EA, Zahs KR 1997 Calcium waves in retinal glial cells. Science 275:844–847

    Article  PubMed  CAS  Google Scholar 

  38. Noetzel MJ 1990 Phosphorylation of the glial fibrillary acidic protein. J Neurosci Res 27:184–192

    Article  PubMed  CAS  Google Scholar 

  39. Gottfried C, Valentim L, Salbego C, Karl J, Wofchuk ST, Rodnight R 1999 Regulation of protein phosphorylation in astrocyte cultures by external calcium ions: specific effects on the phosphorylation of glial fibrillary acidic protein (GFAP), vimentin and heat shock protein 27 (HSP27). Brain Res 833:142–149

    Article  PubMed  CAS  Google Scholar 

  40. Leal RB, Goncalves CA, Rodnight R 1997 Calcium-dependent phosphorylation of glial fibrillary acidic protein (GFAP) in the rat hippocampus: a comparison of the kinase/phosphatase balance in immature and mature slices using tryptic phosphopeptide mapping. Brain Res Dev Brain Res 104:1–10

    Article  PubMed  CAS  Google Scholar 

  41. Wofchuk ST, Rodnight R 1995. Age-dependent changes in the regulation by external calcium ions of the phosphorylation of glial fibrillary acidic protein in slices of rat hippocampus. Brain Res Dev Brain Re.s 85:181–186

    Article  CAS  Google Scholar 

  42. Chattopadhyay N, Legradi G, Bai M, Kifor O, Ye C, Vassilev PM, Brown EM, Lechan RM 1997 Calcium-sensing receptor in the rat hippocampus: a developmental study. Brain Res Dev Brain Res 100:13–21

    Article  PubMed  CAS  Google Scholar 

  43. Penner R, Matthews G, Neher E 1998 Regulation of calcium influx by second messengers in rat mast cells. Nature 334:499–504

    Article  Google Scholar 

  44. Rozengurt E 1986 Early signals in the mitogenic response. Science 234:161–166

    Article  PubMed  CAS  Google Scholar 

  45. von Tscharner V, Prod’hom B, Baggiolini M, Reuter H 1986 Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. Nature 324:369–372

    Article  Google Scholar 

  46. Chin LS, Park CC, Zitnay KM, Sinha M, DiPatri AJ Jr, Perillan P, Simard JM 1997 4-Aminopyridine causes apoptosis and blocks an outward rectifier K+ channel in malignant astrocytoma cell lines. J Neurosci Res 48:122–127

    Article  PubMed  CAS  Google Scholar 

  47. Shanker PP, Wei H, Davee SM, Funk JL 2000 Parathyroid hormone-related protein is expressed by transformed and fetal human astrocytes and inhibits cell proliferation. Brain Res 868:230–240

    Article  Google Scholar 

  48. Struckhoff G, Turzynski A 1995 Demonstration of parathyroid hormone-related protein in meninges and its receptor in astrocytes: evidence for a paracrine meningo-astrocytic loop. Brain Res 676:1–9

    Article  PubMed  CAS  Google Scholar 

  49. Hashimoto H, Aino H, Ogawa N, Nagata S, Baba A 1994 Identification and characterization of parathyroid hormone/parathyroid hormone-related peptide receptor in cultured astrocytes. Biochem Biophys Res Commun 200:1042–1048

    Article  PubMed  CAS  Google Scholar 

  50. Kettenmann H, Banati R, Waltz W 1993 Electrophysiological behavior of microglia. Glia 7:93–101

    Article  PubMed  CAS  Google Scholar 

  51. Ilschner S, Ohlemeyer C, Gimpl G, Kettenmann H 1995 Modulation of potassium currents in cultured murine microglial cells by receptor activation and intracellular pathways. Neuroscience 66:983–1000

    Article  PubMed  CAS  Google Scholar 

  52. Yamaguchi T, Kifor O, Chattopadhyay N, Bai M, Brown EM 1998 Extracellular calcium (Ca2+ o)-sensing receptor in a mouse monocyte-macrophage cell line (J774): potential mediator of the actions of Ca2+ o on the function of J774 cells. J Bone Miner Res 13:1390–1397

    Article  PubMed  CAS  Google Scholar 

  53. Olszak IT, Poznansky MC, Evans RH, Olson D, Kos C, Pollak MR, Brown EM, Scadden DT 2000 Extracellular calcium elicits a chemokinetic response from monocytes in vitro and in vivo. J Clin Invest 105:1299–1305

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Endocrine-Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Chianping Ye Ph.D, Peter M. Vassilev M.D., Ph.D. & Naibedya Chattopadhyay Ph.D.

Authors
  1. Chianping Ye Ph.D
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peter M. Vassilev M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Naibedya Chattopadhyay Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Endocrine-Hypertension Division Department of Medicine, Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts, USA

    Naibedya Chattopadhyay  & Edward M. Brown  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ye, C., Vassilev, P.M., Chattopadhyay, N. (2003). Expression and Functions of Calcium-Sensing Receptor in the Central Nervous System. In: Chattopadhyay, N., Brown, E.M. (eds) Calcium-Sensing Receptor. Endocrine updates, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9256-7_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-9256-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4861-0

  • Online ISBN: 978-1-4419-9256-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation