Abstract
On the basis of the structural characteristics of the 5’-flanking regions of genes encoding the two DNA repair-related enzymes, poly(ADP-ribose) polymerase and DNA polymerase beta, one may suggest that they can be active housekeeping genes (1, 2). The two enzymes are similarly distributed in a number of mouse tissues (3). This indicates that in some circumstances poly(ADP-ribose) polymerase and DNA polymerase beta can possibly be coexpressed. We have shown recently that poly(ADP-ribose) polymerase is induced in proliferating cells during G1/S phase (4, 5). An increase of DNA polymerase beta activity was shown to occur in mitogen-treated peripheral mononuclear cells (PBMC) after DNA synthesis (6). Data on the expression of DNA polymerase beta gene in proliferating cells are so far not available.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ogura, T., Nyunoya, H., Takahashi-Masutani, M., Miwa, M., Sugimura, T., Esumi, H. (1990) Biochem Biophys Res Commun 167: 701–710
Yamaguchi, M., Nishida, Y., Moriuchi, T., Hirose, F., Hui, C. -C, Suzuki, Y., Matsukage, A. (1990) Mol Cell Biol 10: 872–879
Ogura, T., Takeuchi, N., Yamaguchi, M., Matsukage, A., Sugimura, T., Esumi, H. (1990) Biochem Biophys Res Commun 172: 377–384
Menegazzi, M., Gerosa, F., Tommasi, M., Uchida, K., Miwa, M., Sugimura, T., Suzuki, H. (1988) Biochem Biophys Res Commun 156: 995–999
Menegazzi, M., Carcereri De Prati, A., Ledda-Columbano, G. M. Columbano, A., Uchida, T., Miwa, M., Suzuki, H. (1990) Arch Biochem Biophys 279: 232–236
Bertazzoni, U., Stefanini, M., Noy, G. P., Ginlotte, E., Nuzzo, F., Falaschi, A., Spadari, S. (1976) Proc Natl Acad Sci USA 73: 785–789
Zmudzka, B. Z., Fornace, A., Collins, J., Wilson, S. H. (1988) Nuc. Acid Res. 16: 9587–9596.
Spadari, S., Weissbach, A. (1974) J Mol Bio1 86: 11–20
Chiu, R. W., Baril, E. F. (1975) J Biol Chem 250: 7951–7957
Scovassi, A. I., Izzo, R., Franchi, E., Bertazzoni, U. (1986) Eur J Biochen 159: 77–84
Nyunoya, H., Ogura, T., Shiratori, Y., Makino, R., Hayashi, K., Sugimura, T., Miwa, M. (1988) Proc Jpn Cancer Assoc 47: 246
Zmudzka, B. Z., Sen Gupta, D., Matsukage, A., Cobianchi, F., Kumar, P., Wilson, S. H. (1986) Proc Natl Acad Sci 83: 5106–5110
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this paper
Cite this paper
Menegazzi, M. et al. (1992). Expression of the gene for poly(ADP-ribose) polymerase and DNA polymerase beta in rat tissues and in proliferating cells. In: Poirier, G.G., Moreau, P. (eds) ADP-Ribosylation Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8718-1_14
Download citation
DOI: https://doi.org/10.1007/978-1-4419-8718-1_14
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-6456-9
Online ISBN: 978-1-4419-8718-1
eBook Packages: Springer Book Archive