Abstract
The use of two or more drugs simultaneously can be perilous, as shown by the following case:
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Taylor RB. Medical wisdom and doctoring: the art of 21st century medicine. New York: Springer, 2010. Chapter 5.
Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005;352(11):1112–1120.
Block AJ. Revisiting the Libby Zion case. Chest. 1994;105(4):977.
References
Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA. 2002;287(3):337–344.
Riechelmann RP, Moreira F, Smaletz O, Saad ED. Potential for drug interactions in hospitalized cancer patients. Cancer Chemother Pharmacol. 2005;56(3):286–290.
Lima RE, De Bortoli-Cassiani SH. Potential drug interactions in intensive care patients at a teaching hospital. Rev Lat Am Enfermagem. 2009;17(2):222–227.
References
Raebel MA, Carroll NM, Andrade SE, et al. Monitoring of drugs with a narrow therapeutic range in ambulatory care. Am J Manag Care. 2006;12(5):268–274.
Raoof S, Wollschlager C, Kahn FA. Ciprofloxacin increases serum levels of theophylline. Am J Med. 1987;82(4A):115–118.
Adebayo GI, Coker HAB. Cimetidine inhibition of theophylline elimination: the influence of adult age and the time course. Biopharm Drug Dispos. 2006;8(2):149–158.
Renton KW, Gray JD, Hall RI. Decreased elimination of theophylline after influenza vaccination. Can Med Assoc J. 1980;123(4):288–290.
References
Dickinson BD, Altman RD, Nielson NH, Sterling ML, for the Council on Scientific Affairs, American Medical Association. Obstet Gyn. 2001;98(5):853–860.
Archer JSM, Archer DF. Oral contraceptives efficacy and antibiotic interaction: a myth debunked. J Am Acad Dermatol. 2002;46(6):917–923.
Reference
Steinman MA, Landefeld CS, Rosenthal GE, Berthenthal D, Sen S, Kaboli PJ. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc. 2006;54(10):1516–1523.
References
Gladding PA, Webster MW, Farrell HB, Zeng IS, Park R, Ruijne N. The antiplatelet effect of six non-steroidal anti-inflammatory drugs and their pharmacodynamic interaction with aspirin in healthy volunteers. Am J Cardiol. 2008;101(7):1060–1063.
Rimon G, Sidhu RS, Lauver DA, et al. Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1. Proc Natl Acad Sci U S A. 2010;107(1):28–33.
Nainggolan L. Celecoxib could impede effects of low-dose aspirin. Medscape. Available at http://www.medscape.com/viewarticle/714041?src=mpnews&spon=34&uac=95007MG/. Accessed April 12, 2010.
Reference
Phelan KM, Mosholdler AD, Lu S. Lithium interaction with the cyclooxygenase 2 inhibitors rofecoxib and celecoxib and other nonsteroidal anti-inflammatory agents. J Clin Psychiatry. 2003;64(11):1328–1334.
Reference
Steinhubl SR, Bhatt DL, Brennan DM. Aspirin to prevent cardiovascular disease: the association of aspirin dose and clopidogrel with thrombosis and bleeding. Ann Intern Med. 2009;150(6):379–386.
References
Information for Healthcare Professionals: Update to the labeling of clopidogrel bisulfate (marketed as Plavix) to alert healthcare professionals about a drug interaction with omeprazole (marketed as Prilosec and Prilosec OTC). U.S. Food and Drug Administration. Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm190787.htm/. Accessed April 12, 2010.
Gilard M, Arnaud B, Cornily JC, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole Clopidogrel Aspirin) study. J Am Coll Cardiol. 2008;51(3):256–260.
Ho PM, Maddox TM, Want L, et al. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA. 2009;301(9):937–944.
Siller-Matula JM, Spiel AO, Lang IM, Kreiner G, Christ G, Jilma B. Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel. Am Heart J. 2009;157(1):148.e1–e5.
O’Donoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton pump inhibitor: an analysis of two randomized trials. Lancet. 2009;374(9694):989–997.
Laine L, Henneken C. Proton pump inhibitor and clopidogrel interaction: fact or fiction? Am J Gastroenterol. 2009;105(1):34–41.
Ray WA, Murray KT, Griffin MR, et al. Outcomes with concurrent use of clopidogrel and proton-pump inhibitor. Ann Intern Med. 2010;152(6):337–345.
Rassen JA, Choudhry NK, Avorn J, Schneeweiss S. Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome. Circulation. 2009;120(23):2322–2329.
References
Reeves RR, Mack JE. Possible dangerous interaction of OxyContin and carisoprodol. Am Fam Phys. 2003;67(11):2273.
Owens C, Pugmire B, Salness T, et al. Abuse potential of carisoprodol: a retrospective review of Idaho Medicaid pharmacy and medical claims data. Clin Ther. 2007;29(10):2222–2225.
References
Kelly CM, Juurlink DN, Gomes T, et al. Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study. BMJ. 2010;340:c693. doi: 10.1136/bmj.c693.
Hoskins JM, Carey LA, McLeod HL. CYP2D6 and tamoxifen: DNA matters in breast cancer. Nat Rev Cancer. 2009;9(8):576–586.
Tamoxifen, SSRIs, and breast cancer recurrence. Pharmacology Watch. September, 2009; page 1.
Lash TL, Cronin-Fentin D, Ahern TP, et al. Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen. Acta Oncol. 2010;49(3):305–312.
References
Jiao X, Velez S, Ringstad J, Eyma V, Miller D, Bleiberg M. Myocardial infarction associated with Adderall XR and alcohol use in a young man. J Am Board Fam Med. 2009;22(2):197–201.
Rosak J. U.S. regulators puzzled by Canada’s ruling on safety of ADHD drug. Psychiatric News. 2005;40(5):2.
References
ONTARGET Investigators, Yusef S, Teo KK, Pogue J, et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008;358(15):1547–1559.
Mann JF, Schmieder RE, McQueen M, et al (ONTARGET Investigators). Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomized, double-blind controlled trial. Lancet. 2008;372(9638):547–553.
Taylor RB. The clinician’s guide to medical writing. New York: Springer, 2005; page 217.
Reference
Antoniou T, Gomes T, Juurlink DN, et al. Trimethoprim–sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin–angiotensin system. Arch Intern Med. 2010;170(12):1045–1049.
References
Chang JT, Staffa JA, Parks M, Green L. Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy. Pharmacoepidemiol Drug Saf. 2004;13(7):417–426.
ACCORD Study Group. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med. 2010;362(17):1563–1574.
References
Ridtitid W, Wongnawa M, Mahatthanatrakul W, Raungsri N, Sunbhanich M. Ketoconazole increases plasma concentrations of antimalarial mefloquine in healthy human volunteers. J Clin Pharm Ther. 2005;30:285–290.
Sowunmi A, Adio RA, Oduola AM, Ogundahunsi OA, Salako LA. Acute psychosis after mefloquine: report of six cases. Trop Geogr Med. 1995;47(4):179–180.
Ridtitid W, Wongnawa M, Mahatthanatrakul W, Chaipol P, Sunbhanich M. Effect of rifampin on plasma concentrations of mefloquine in healthy volunteers. J Pharm Pharmacol. 2000;52(10):1265–1269.
References
Zapater P, Reus S, Tello A, Torrus D, Perez-Mateo M, Horga JF. A prospective study of the clarithromycin–digoxin interaction in elderly patients. J Antimicrob Chemother. 2002;50(4):601–606.
Tanaka H, Matsumoto K, Ueno K, Kodama M, Yoneda K, Katayama Y, Miyatake K. Effect of clarithromycin on steady-state digoxin concentrations. Ann Pharmacother. 2003;37(2):178–181.
Reference
Nurnberg HG, Hensley PL, Heiman JR, Croft HA, Debattista C, Paine S. Sildenafil treatment of women with antidepressant-associated sexual dysfunction: a randomized controlled trial. JAMA. 2008;300(4):395–404.
References
Kloner RA, Hutter AM, Emmick JT, Mitchell ML, Denne J, Jackson G. Time course of the interaction between tadalafil and nitrates. J Am Coll Cardiol. 2003;42(10):1855–1860.
Tadalafil (Cialis). Epocrates Online. Available at: https://online.epocrates.com/u/10a3560?src=PK/. Accessed March 25, 2010.
Reference
de Leon J, Armstrong SC, Cozza KL. The dosing of atypical antipsychotics. Psychosomatics. 2005;46(3):262–273.
Reference
Blier P, Ward HE, Tremblay P, et al. Combination of antidepressant medications from treatment initiation for major depressive disorder: a double-blind randomized study. Am J Psychiatry. 2010;167(3):281–288.
References
Holbrook AM, Pereira JA, Labiris R, et al. Systematic overview of warfarin and its drug and food interactions. Arch Int Med. 2005;165:1095–1106.
Ament PW, Bertolino JG, Liszewski JL. Clinically significant drug interactions. Am Fam Phys. 2000;61:1745–1754.
Gardner P, Phillips R, Shaughnessy AF. Herbal and dietary supplements: drug interactions in patients with chronic illnesses. Am Fam Phys. 2008;77(1):73–78.
Grant P. Warfarin and cranberry juice: an interaction? J Heart Valve Dis. 2004;13(1):25–26.
Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ. 2003;327(7429):1454.
Buckley MS, Goff AD, Knapp WE. Fish oil interaction with warfarin. Ann Pharmacother. 2004;38(1):50–52.
Schelleman H, Bilker WB, Brensinger CM, et al. Fibrate/statin initiation in warfarin users and gastrointestinal bleeding risk. Am J Med. 2010;123(2);151–157.
Fischer HD, Juurlink DN, Mamdani MM, Koop A, Laupacis A. Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based study. Arch Intern Med. 2010;170(7):617–621.
Jiang X, Williams KM, Liauw WS, et al. Effect of St John’s wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol. 2004;57(5):592–599.
Taylor RB. White coat tales – medicine’s heroes, heritage and misadventures. New York: Springer, 2008; page 62.
References
Andrén L, Andreasson A, Eggertsen R. Interaction between a commercially available St. John’s wort product (Movina) and atorvastatin in patients with hypercholesterolemia. Eur J Clin Pharmacol. 2007;63(10):913–916.
McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ. 1996;155(3):293–295.
Gardner P, Phillips R, Shaughnessy AF. Herbal and dietary supplements: drug interactions in patients with chronic illnesses. Am Fam Phys. 2008;77(1):73–78.
References
Kale-Pradhan PB, Jassai HD, Wilhelm SM. Role of Lactobacillus in the prevention of antibiotic-associated diarrhea: a meta-analysis. Pharmacotherapy. 2010;30(2):119–129.
Kotowska M, Albrecht P, Szajewska H. Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea in children: a randomized double-blind placebo-controlled trial. Aliment Pharmacol Ther. 2005;21(5):583–590.
Hickson M, D’Souza AL, Muthu N. Use of probiotic Lactobacillus preparation to prevent diarrhea associated the antibiotics: randomized double blind placebo controlled trial. BMJ. 2007;335(7610):80.
References
Fuhr U. Drug interactions with grapefruit juice: extent, probable mechanism and clinical relevance. Drug Safety. 1998;18(4):251–272.
Arayne MS, Sultana N, Bibi Z. Grapefruit juice–drug interactions. Pak J Pharm Sci. 2005;18(4):45–57.
Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice–drug interactions. Br J Clin Pharmacol. 1998;46(2):101–110.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Taylor, R.B. (2011). Drug Interactions and Adventures in Polypharmacy. In: Essential Medical Facts Every Clinician Should Know. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7874-5_11
Download citation
DOI: https://doi.org/10.1007/978-1-4419-7874-5_11
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-7873-8
Online ISBN: 978-1-4419-7874-5
eBook Packages: MedicineMedicine (R0)