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KSRP Promotes the Maturation of a Group of miRNA Precuresors

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Book cover Regulation of microRNAs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 700))

Abstract

microrNNA (mirNAs) are small noncoding RNAs that down-regulate gene expression by reducing stability and/or translation of target mRNAs. In animals, miRNAs arise from sequential processing of hairpin primary transcripts by two rNase III domain-containing enzymes, namely Drosha and Dicer, to generate a mature form of about 22 nucleotides. In this chapter we discuss our latest fndings indicating that KSRP is an integral component of both Drosha and Dicer complexes. KSRP binds to the terminal loop sequence of a subset of miRNA precursors promoting their maturation. our data indicate that the terminal loop is a pivotal structure where activators of miRNA processing as well as repressors of miRNA processing act in a coordinated way to convert cellular signals into changes in miRNA expression processing. This uncovers a new level of complexity of miRNA mechanisms for gene expression regulation.

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Author information

Authors and Affiliations

  1. Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, room 345, La Jolla, California, USA

    Michele Trabucchi

Authors
  1. Michele Trabucchi
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  2. Paola Briata
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  3. Witold Filipowicz
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  4. Andres Ramos
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  5. Roberto Gherzi
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  6. Michael G. Rosenfeld
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Editors and Affiliations

  1. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

    Helge Großhans

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© 2010 Landes Bioscience and Springer Science+Business Media, LLC

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Trabucchi, M., Briata, P., Filipowicz, W., Ramos, A., Gherzi, R., Rosenfeld, M.G. (2010). KSRP Promotes the Maturation of a Group of miRNA Precuresors. In: Großhans, H. (eds) Regulation of microRNAs. Advances in Experimental Medicine and Biology, vol 700. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7823-3_4

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