Abstract
Overweight and obesity are the most common nutritional disorders in our age and are becoming more and more common worldwide. The most harmful consequences of an incorrect diet leading to overweight or obesity are a series of cardio-vascular diseases often leading to disability and death. In recent years various studies have shown that a reduction in caloric intake is the main factor involved in reduction of pathology risk. In this article, a nutrition strategy, based on the Zone diet by US biochemist Dr. Barry Sears is proposed. It underlines the importance of choosing certain types of foods over others, their beneficial physiological effects on the human body and how they can reduce the risk of heart disease and cancer.
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References
Grundy SM, Hansen B, Smith SC et al. Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung and Blood Institute/American Diabetes. Circulation 2004; 109:551–556.
Yoshino M, Kuhlmann MK, Kotanko P et al. International differences in dialysis mortality reflect background general population atherosclerotic cardiovascular mortality. J Am Soc Nephrol 2006; 17:3510–3519.
Conroy RM, Pyorala K, Fitzgerald AP et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 2003; 24(11):987–1003.
Parekh RS, Zhang L, Fivush BA et al. Incidence of atherosclerosis by race in the dialysis morbidity and mortality study: A sample of the US ESRD population. J Am Soc Nephrol 2005; 16:1420–1426.
Kremer JM, Lawrence DA, Petrillo GF et al. Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs. Clinical and immune correlates. Arthritis Rheum 1995; 38:1107–1114.
Belluzzi A, Boschi S, Brignola C et al. Effect of an enteric-coated fish-oil preparation on relapses in Crohn’s disease. N Engl J Med 1996; 354:1557–1560.
Tang K and Honn KV. 12(S)-HETE in cancer metastasis. Adv Exp Med Biol 1999; 447:181–191.
Austin MA, Breslow JL, Hennekens CH et al. Low density lipoprotein subclass patterns and risk of myocardinal infarction. JAMA 1988; 260:1917–1920.
Jeppesen J, Hein HO, Suadicani P et al. “Low triglycerides-high high-density lipoprotein cholesterol and risk of ischemic heart disease.” Arch Intern Med 2001; 161:361–366.
Lamarche B, Lemieux I, Despres JP. “The small dense phenotype and the risk of coronary heart disease epidemiology, pathophysiology and therapeutic aspects.” Diabetes Metab 1999; 25:199–211.
Gaziano JM, Hennekens CH, O’Donnell CJ et al. “Fasting triglycerides, high-density lipoproteins and risk of myocardial infarction.” Circulation 1997; 96:2520–2525.
GISSI-Prevenzione Investigators. “Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial.” Lancet 1999; 354:447–455.
Sears B. The Zone. New York: Regan Books, 1995.
Sears B. The Anti-Aging Zone. New York: Regan Books, 1999.
Sears B. The Omega Rx Zone. New York: Regan Books, 2002.
Jenkins DJ, Wolever TM, Taylor RH et al. The glycaemic index of foods tested in diabetic patients: a new basis for carbohydrate exchange favouring the use of legumes. Diabetologia 1983; 24(4):257–264.
Jenkins DJ, Wolever TM, Taylor RH et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 1981; 34(3):362–366.
Takeda E, Arai H, Muto K et al. Gene expression in low glycemic index diet—impact on metabolic control. Forum Nutr 2007; 60:127–139.
Wolfe MS, Sawyer JK, Morgan TM et al. Dietary polyunsaturated fat decreases coronary artery atherosclerosis in a pediatric-aged population of African green monkeys. Arterioscler Thromb 1994; 14:587–597.
Lapinleimu H. “Prospective randomised trial in 1062 infants of diet low in saturated fat and cholesterol”. Lancet 1995; 345(8948):471–476.
Fuentes F, Lopez-Miranda J, Sanchez E et al. Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Ann Intern Med 2001; 134(12): 1115–1119.
Rivellese AA, Maffettone A, Vessby B et al. “Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and postprandial lipid metabolism in healthy subjects”. Atherosclerosis 2003; 167(1):149–158.
Hu FB, Stampfer MJ, Manson JAE et al. “Dietary fat intake and the risk of coronary heart disease in women”. N Engl J Med 1997; 337(21):1491–1499.
United States Food and Drug Administration (September 8, 2004). FDA announces qualified health claims for omega-3 fatty acids. Press release.
Sears B. The OmegaZone Dietary Program and Eicosanoid Modulation. The Role of Eicosanoids and Chronic Disease. www.zonelabsinc.com
Diplock AT, Aggett PJ, Ashwell M et al. Scientific concepts of functional foods in Europe—consensus document. British Journal of Nutrition 1999; 81(1):1–27.
Sears B. Omega/Rx ingredients. http://www.zonediet.com/OMEGA3/tabid/64/Default.aspx
Siegel-Axel D, Daub K, Seizer P et al. Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis. Cardiovasc Res 2008; 78(1):8–17.
Soininen P, Öörni K, Maaheimo H et al. 1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins. Biochem Biophys Res Commun 2007; 360(1,17):290–294.
Matsuura E, Kobayashi K, Tabuchi M et al. Oxidative modification of low-density lipoprotein and immune regulation of atherosclerosis. Prog Lipid Res 2006; 45(6):466–486.
Kaliora AC, Dedoussis GVZ, Schmidt H. Dietary antioxidants in preventing atherogenesis. Atherosclerosis 2006; 187(1):1–17.
Turner R, Etienne N, Alonso MG et al. Antioxidant and anti-atherogenic activities of olive oil phenolics. Int J Vitam Nutr Res 2005; 75(1):61–70.
Akila M, Devaraj H. Synergistic effect of tincture of Crataegus and Mangifera indica L. extract on hyperlipidemic and antioxidant status in atherogenic rats. Vascular Pharmacology 2008; 49(4–6):173–177.
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Lavecchia, T., Petroni, P., Rodio, G., Pina, R. (2010). A Nutritional Strategy for Reducing Disease and Obesity Risks. In: Giardi, M.T., Rea, G., Berra, B. (eds) Bio-Farms for Nutraceuticals. Advances in Experimental Medicine and Biology, vol 698. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7347-4_6
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DOI: https://doi.org/10.1007/978-1-4419-7347-4_6
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