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Advances in Systems Biology pp 313–323Cite as

Receptor Dynamics in Signaling

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 736))

Abstract

Reliable inter- and intracellular communication is central to both the development and the integrity of multicellular organisms. Key mediators of these processes are cell surface receptors that perceive and convert extracellular cues to trigger intracellular signaling networks and ultimately a phenotypic response. Deregulation of signal transduction leads to a variety of diseases, and aberrations in receptor proteins are very common in various cancer types. Therefore, cell surface receptors have been established as major targets in drug discovery. However, in order to efficiently apply therapeutics, it is crucial to gain knowledge about design principles of receptor signaling. In this chapter, we will discuss signal transduction at the receptor level for examples from different receptor classes.

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Acknowledgments

This work was supported by the Helmholtz Alliance on Systems Biology (SBCancer) (VB, JT, UK), the German Federal Ministry of Education and Research (BMBF)-funded MedSys-Network LungSys (JT, UK), and the Excellence Initiative of the German Federal and State Governments (EXC 294) (JT).

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Author notes

  1. Verena Becker

    Present address: Department of Systems Biology, Harvard Medical School, Boston, MA, USA

Authors and Affiliations

  1. Division Systems Biology of Signal Transduction, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany

    Verena Becker & Ursula Klingmüller

  2. Bioquant, Heidelberg University, Heidelberg, Germany

    Verena Becker & Ursula Klingmüller

  3. BIOSS Centre for Biological Signalling Studies, Freiburg Institute for Advanced Studies, Institute of Physics, Center for Systems Biology, University of Freiburg, Freiburg, Germany

    Jens Timmer

Authors
  1. Verena Becker
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  2. Jens Timmer
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  3. Ursula Klingmüller
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Corresponding author

Correspondence to Verena Becker .

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Editors and Affiliations

  1. School of Informatics, University of Edinburgh, Crichton Street 10, Edinburgh, EH89AB, UK

    Igor I. Goryanin

  2. School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh, EH93JR, UK

    Andrew B. Goryachev

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Becker, V., Timmer, J., Klingmüller, U. (2012). Receptor Dynamics in Signaling. In: Goryanin, I.I., Goryachev, A.B. (eds) Advances in Systems Biology. Advances in Experimental Medicine and Biology, vol 736. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7210-1_18

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