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Genomics, Proteomics, and the Nervous System pp 195–225Cite as

Genomic Imprinting and Sexual Experience-Dependent Learning in the Mouse

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Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 2))

Abstract

Sexual experience is a significant modulator of behaviour in male rodents, inducing mating behaviour changes, increased sexual motivation and olfactory learning. Sexually experienced males exhibit greater motivation to investigate females and show preferences for receptive oestrous females and their odours which are not seen in virgins. These behavioural effects of sexual experience are accompanied by neurobiological changes affecting forebrain sensitivity to steroid hormones, mesolimbic dopamine function and neural activity in the basal hypothalamus and olfactory pathways. These changes suggest that sexually experienced males are better able to detect receptive females, are more motivated to pursue them and are more proficient copulators. Furthermore, this response to sexual experience appears to be mediated by imprinted genes. Imprinted genes are a small class of mammalian autosomal genes that are expressed in parent-of-origin fashion and which are key regulators of placentation and development in mammals. Mice carrying a knockout of the paternally expressed gene Peg3 have deficits in maternal care and offspring development, but Peg3 mutant males also fail to show any sexual experience-dependent changes in behaviour or learned olfactory preferences. There are also no changes in female odour-evoked neural activity in the hypothalamus, vomeronasal system or main olfactory pathway of Peg3 mutants after sexual experience, suggesting a deficit in sexual experience-dependent forebrain plasticity. Peg3 appears to regulate male behavioural traits that would enhance its own transmission down the male line, suggesting that this imprinted gene has evolved to directly influence plasticity in male reproductive behaviour.

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  1. Behavioural Biology and Helmholtz Institute, Utrecht University, 3508 TB, Utrecht, The Netherlands

    William T. Swaney

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    James D Clelland

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Swaney, W.T., Keverne, E.B. (2011). Genomic Imprinting and Sexual Experience-Dependent Learning in the Mouse. In: Clelland, J. (eds) Genomics, Proteomics, and the Nervous System. Advances in Neurobiology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7197-5_8

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