Abstract
End stage heart failure following myocardial infarction is a major health problem despite significant improvement in treatment intervention. Heart transplantation is the only option to treat end stage heart failure patients, however; the supply needed has severe shortage. Therefore, cell transplantation has gained significant interest as a future treatment of various heart diseases including myocardial infarction. Optimal cell type for complete cardiac regeneration is still needed as clinical trials using adult stem cell transplantation so far did not show long-term significant improvement in cardiac function. Moreover, there are concerns over the differentiation of adult stem cells into cardiac cell types. Embryonic stem cells can be used for cell transplantation but their potential in clinical trial has been hampered due to their characteristics of teratoma formation. Furthermore, beneficial effects observed in clinical and experimental studies that may be associated with released autocrine or paracrine factors following cell transplantation is another major area of current investigation discussed in this review.
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Singla, D.K. (2011). Cardiac Cell Therapy: Present and Future. In: Dhalla, N., Nagano, M., Ostadal, B. (eds) Molecular Defects in Cardiovascular Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7130-2_7
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DOI: https://doi.org/10.1007/978-1-4419-7130-2_7
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