Abstract
The rationale for studies to repopulate the liver with transplanted cells is essentially based on three observations: (1) The well-known finding that the liver can fully regenerate after acute hepatotoxic injury or surgical reduction in liver mass, (2) the regenerated liver functions normally, without long-term impairment, and (3) a unique portal (venous to venous) circulation exists in the liver that provides ready access of transplanted cells to the parenchyma through the hepatic sinusoids.
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The authors would like to thank Anna Caponigro and Emily Bobe for assistance in typing this manuscript.
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Shafritz, D.A., Oertel, M., Dabeva, M.D. (2011). Hepatic Progenitors in Development and Transplantation. In: Monga, S. (eds) Molecular Pathology of Liver Diseases. Molecular Pathology Library, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7107-4_16
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