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The Human Vaginal Microbiome

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Book cover Metagenomics of the Human Body

Abstract

Humans live in association with abundant, complex, and dynamic microbial populations (the microbiome) that colonize many body sites, including the vaginal tract. Interactions between the host and the vaginal microbiota greatly affect women’s health, where they often serve a protective role in maintaining vaginal health. Disruption of the microbial composition can lead to increased susceptibility to various urogenital diseases, including bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), pelvic inflammatory disease (PID), and sexually transmitted diseases (STDs) such as infection with Chlamydia, Trichomonas, and human immunodeficiency virus (HIV). The composition of the vaginal microbiota also has a notable impact on pregnancy and neonatal outcome, including complications such as preterm labor and delivery. Understanding the composition and dynamics of the vaginal ecosystem as well as the involvement of metabolic and immunologic components is an area of increasing interest and research.

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Authors and Affiliations

  1. Host-Microbe Systems Theme, Department of Microbiology, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 601 South Goodwin Ave., Urbana, IL, 61801, USA

    Brenda A. Wilson

  2. University of Illinois at Urbana-Champaign, 601 East John Street, Champaign, IL, 61820-5711, USA

    Susan M. Thomas

  3. Department of Microbiology, University of Illinois at Urbana-Champaign, 601 East John St., Champaign, IL, 61820-5711, USA

    Mengfei Ho

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  1. Brenda A. Wilson
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  2. Susan M. Thomas
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  3. Mengfei Ho
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Correspondence to Brenda A. Wilson .

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  1. J. Craig Venter Institute (JCVI), 9704 Medical Center Drive, Rockville, 20850, Maryland, USA

    Karen E. Nelson

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Wilson, B.A., Thomas, S.M., Ho, M. (2011). The Human Vaginal Microbiome. In: Nelson, K. (eds) Metagenomics of the Human Body. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7089-3_6

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