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Cancer, Carcinogenesis, and Aging

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Principles and Practice of Geriatric Surgery

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Abstract

Cancer is mainly a disease of aging. At present 50% of all cancers occur in the 12% of the population aged 65 and older [1]. By the year 2030, individuals over 65 years will represent 20% of the population of the United States and account for 70% of all cancers [1, 2]. The management of cancer in the older age group is going to become the most common practice of oncology.

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References

  1. Balducci L, Ershler WB (2005) Cancer and ageing: a nexus at several levels. Nat Rev Cancer 5:655–662

    Article  PubMed  CAS  Google Scholar 

  2. Yancik R (2005) Population aging and cancer: a cross national problem. Cancer J 11(6):437–441

    Article  PubMed  Google Scholar 

  3. Stanta G (2004) Morbid anatomy of aging. In: Balducci L, Lyman GH, Ershler WB, Extermann M (eds) Comprehensive geriatric oncology, 2nd edn. Taylor & Francis, London, pp 187–193

    Google Scholar 

  4. Jemal A, Thun MJ, Ries LA et al (2008) Annual report to the nation on the status of cancer: 1975–2005. Featuring trend in lung cancer, tobacco use and tobacco control. J Natl Cancer Inst 100(23): 1672–1694

    Article  PubMed  Google Scholar 

  5. Diab SG, Elledge RM, Clark GM (2000) Clinical characteristics and outcome of elderly women with breast cancer. J Natl Cancer Inst 92(7):550–556

    Article  PubMed  CAS  Google Scholar 

  6. Repetto L, Venturino A, Gianni W (2004) Prognostic evaluation for the older cancer patient. In: Balducci L, Lyman GH, Ershler WB, Extermann M (eds) Comprehensive geriatric oncology, 2nd edn. Taylor & Francis, London, pp 309–322

    Google Scholar 

  7. Kanapuru B, Posani K, Muller D, Ershler WB (2008) Decreased cancer prevalence in the nursing home. J Am Geriatr Soc 56(11):2165–2166

    Article  PubMed  Google Scholar 

  8. Goodwin JS, Osborne C (2004) Factors affecting the diagnosis and treatment of older patients with cancer. In: Balducci L, Lyman GH, Ershler WB, Extermann M (eds) Comprehensive geriatric oncology, 2nd edn. Taylor & Francis, London, pp 56–66

    Google Scholar 

  9. Luciani A, Balducci L (2004) Mutiple primary malignancies. Semin Oncol 31:264–273

    Article  PubMed  Google Scholar 

  10. Schaapveld M, Visser O, Lowman MJ et al (2008) Risk of new primary non-breast cancers after breast cancer treatment: a Dutch population-based study. J Clin Oncol 26(8):1239–1246

    Article  PubMed  Google Scholar 

  11. Muss HB, Berry DA, Cirrincione C et al (2007) Toxicity of older and younger patients treated with adjuvant chemotherapy for node-positive breast cancer: the Cancer and Leukemia Group B Experience. J Clin Oncol 25(24):3699–3704

    Article  PubMed  CAS  Google Scholar 

  12. Patt DA, Duan Z, Fang S et al (2007) Acute myeloid leukemia after adjuvant breast cancer therapy in older women: understanding risk. J Clin Oncol 25(25):3871–3876

    Article  PubMed  Google Scholar 

  13. Hershman D, Neugut AI, Jacobson JS et al (2007) Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. J Natl Cancer Inst 99(3):196–205

    Article  PubMed  CAS  Google Scholar 

  14. Holmes FF (2004) Clinical evidence for change in tumor aggressiveness with age: a historical perspective. In: Balducci L, Lyman GH, Ershler WB, Extermann M (eds) Comprehensive geriatric oncology, 2nd edn. Taylor & Francis, London, pp 180–186

    Google Scholar 

  15. Jemal A, Siegel R, Ward E et al (2008) Cancer statistics. CA Cancer J Clin 58(2):71–96

    Article  PubMed  Google Scholar 

  16. Hershman DL, McBride RB, Eisenberger A (2008) Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B cell non-Hodgkin’s lymphoma. J Clin Oncol 26(19):3159–3165

    Article  PubMed  CAS  Google Scholar 

  17. Doyle JJ, Neugut AI, Jacobson JS (2005) Chemotherapy and cardiotoxicity in older breast cancer patients: a population based study. J Clin Oncol 23(34):8597–8605

    Article  PubMed  Google Scholar 

  18. Swain SM, Whaley FS, Ewer MS (2003) Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer 97(11):2869–2879

    Article  PubMed  CAS  Google Scholar 

  19. Heck JE, Albert SM, Franco R, Gorin SS (2008) Pattern of dementia diagnosis in surveillance, epidemiology and end results breast cancer survivors who use chemotherapy. J Am Geriatr Soc 56(9):1687–1692

    Article  PubMed  Google Scholar 

  20. Shainian VB, Kuo YE, Freeman JL et al (2005) Risk of bone fracture after androgen deprivation in prostate cancer. N Engl J Med 352:154–164

    Article  Google Scholar 

  21. Leahy Y (2008) Risk of metabolic syndrome, cardiovascular diseases and diabetes in androgen deprivation therapy. Clin J Oncol Nurs 12(5):771–776

    Article  PubMed  Google Scholar 

  22. Balducci L, Beghé C (2002) Prevention of cancer in the older aged person. Clin Geriatr Med 18(3):505–528

    Article  PubMed  Google Scholar 

  23. Anisimov VN (2009) Carcinogenesis and aging 20 year after: escaping horizon. Mech Ageing Dev 130(1–2):105–121

    Article  PubMed  CAS  Google Scholar 

  24. Schwartsburd PM (2004) Aging-promoted creation of a pro-cancer microenvironment by inflammation: pathogenesis of dyscoordinated feed-back control. Mech Ageing Dev 125(9):581–590, Review

    Article  PubMed  CAS  Google Scholar 

  25. Khatami M (2008) Yin and Yang in inflammation: duality in immune cell function and tumorigenesis. Expert Opin Biol Ther 8(10):1461–1472

    Article  PubMed  CAS  Google Scholar 

  26. Vasto S, Carruba G, Lio D (2008) Inflammation, ageing and cancer. Mech Ageing Dev 130(1–2):40–45

    PubMed  Google Scholar 

  27. Kaklamani VG, Wisinski KB, Sadim M et al (2008) Variants of adiponectin and adiponectin receptor 1 genes and colorectal cancer. JAMA 300(13):1523–1531

    Article  PubMed  CAS  Google Scholar 

  28. Campisi J (2008) Aging and cancer cell biology. Aging Cell 7(3): 281–284

    Article  PubMed  CAS  Google Scholar 

  29. Campisi J, d’Adda di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8(9): 729–740

    Article  PubMed  CAS  Google Scholar 

  30. List AF (2008) Treatment strategies to optimize clinical benefits in patients with myelodysplastic syndromes. Cancer Control 15(Suppl):29–39

    PubMed  Google Scholar 

  31. Ershler WB (2004) Tumor-host interactions, aging, and tumor growth. In: Balducci L, Lyman GH, Ershler WB, Extermann M (eds) Comprehensive geriatric oncology, 2nd edn. Taylor & Francis, London, pp 147–157

    Google Scholar 

  32. Gingerich J, Bow EJ (2006) Approach to the complications of treatment of acute leukemia in the elderly. Semin Hematol 43(2):134–143, Review

    Article  PubMed  Google Scholar 

  33. Anders CK, Hsu DS, Broadwater G et al (2008) Young age at diagnosis correlated with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol 26(20):3324–3330

    Article  PubMed  Google Scholar 

  34. Nixon AJ, Neuberg D, Hayes DF et al (1994) Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol 12:888–894

    PubMed  CAS  Google Scholar 

  35. Jacobi N, Peterson BA (2008) Non-Hodgkin lymphoma. In: Balducci L, Ershler WB, DeGaetano G (eds) Blood disorders in the elderly. Cambridge University Press, Cambridge, pp 290–310

    Google Scholar 

  36. Lenz G, Wright G, Dave SS et al (2008) Stromal gene signatures in large cell lynphomas. N Engl J Med 359(22):2313–2323

    Article  PubMed  CAS  Google Scholar 

  37. Vogel VG, Costantino JP, Wickerham DL et al (2006) Effects of Tamoxifen vs Raloxifen on the risk of development of invasive breast cancer and other disease outcome: the NSABP study of Tamoxifen vs Raloxifen (STAR) P2 trial. JAMA 295(23): 2727–2741

    Article  PubMed  CAS  Google Scholar 

  38. Thompson IM, Goodman PJ, Tangen CM et al (2003) The influence of finasteride on the development of prostate cancer. N Engl J Med 349(3):215–224

    Article  PubMed  CAS  Google Scholar 

  39. Masquera M, Fleshner NE, Finelli A et al (2008) The REDUCE trial: chemoprevention in prostate cancer using a dual 5alpha-reductase inhibitor, dutasteride. Expert Rev Anticancer Ther 8: 1073–1079

    Article  Google Scholar 

  40. Klass CM, Shin DM (2007) Current status and future perspectives of chemoprevention of head and neck cancer. Curr Cancer Drug Targets 7(7):623–632

    Article  PubMed  CAS  Google Scholar 

  41. Antonakopoulos N, Karamanolis DG (2007) The role of NSAID in colon cancer prevention. Hepatogastroenterology 54(78): 1694–1700

    PubMed  CAS  Google Scholar 

  42. Browning DR, Martin RM (2007) Statins and risk of cancer: a systematic review and meta-analysis. Int J Cancer 120:833–843

    Article  PubMed  CAS  Google Scholar 

  43. McCarthy EP, Burns RB, Freund KM (2000) Mammography use, breast cancer stage at diagnosis and survival among older women. J Am Geriatr Soc 48(10):1226–1233

    PubMed  CAS  Google Scholar 

  44. McPherson CP, Swenson KK, Lee MW (2002) The effects of mammographic detection and comorbidity on survival of older women with breast cancer. J Am Geriatr Soc 50(6):1061–1068

    Article  PubMed  Google Scholar 

  45. Walter LC, Lewis CL, Barton MB (2005) Screening for colorectal, breast, and cervical cancer in the elderly: a review of the evidence. Am J Med 118(10):1078–1086

    Article  PubMed  Google Scholar 

  46. U.S. Preventive Services Task Force (2008) U.S. Preventive Services Task Force: screening for prostate cancer. USPSTF recommendations. Ann Intern Med 149(3):185–191

    Google Scholar 

  47. Balducci L, Cohen HJ, Engtrom P et al (2005) Senior adult oncology clinical practice guidelines in oncology. J Natl Compr Canc Netw 3:572–590

    PubMed  Google Scholar 

  48. Manton KG, Gu X, Lowrimore GR (2008) Cohort changes in active life expectancy in the US elderly population: experience from the 1982–2004 National Long Term Care Survey. J Gerontol B Psychol Sci Soc Sci 63(5):S269–S281

    Article  PubMed  Google Scholar 

  49. Lee SJ, Lindquist K, Segal MR et al (2006) Development and validation of a prognostic index for 4-year mortality in older adults. JAMA 295(7):801–808

    Article  PubMed  CAS  Google Scholar 

  50. Carey EC, Covinsky KE, Lui LY et al (2008) Prediction of mortality in community-living frail elderly people with long-term care needs. J Am Geriatr Soc 56(1):68–75

    Article  PubMed  Google Scholar 

  51. Rockwood K, Mitnitski A, Song X et al (2006) Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc 54(6):975–979

    Article  PubMed  Google Scholar 

  52. Maas HA, Janssen-Heijnen ML, Olde Rikkert MG et al (2007) Comprehensive geriatric assessment and its impact in oncology. Eur J Cancer 43(15):2161–2169

    Article  PubMed  Google Scholar 

  53. Rodin MB, Mohile SG (2007) A practical approach to geriatric assessment in oncology. J Clin Oncol 25(14):1936–1944

    Article  PubMed  Google Scholar 

  54. Extermann M, Chen A, Cantor AB et al (2002) Predictors of tolerance of chemotherapy in older patients. Eur J Cancer 38:1466–1473

    Article  PubMed  CAS  Google Scholar 

  55. Ozair S, Iqbal S (2008) Efficacy and safety of aromatase inhibitors in early breast cancer. Expert Opin Drug Saf 7(5):547–558, Review

    Article  PubMed  CAS  Google Scholar 

  56. Boccon-Gibod L, Hammerer P, Madersbacher S et al (2007) The role of intermittent androgen deprivation in prostate cancer. BJU Int 100(4):738–743

    Article  PubMed  CAS  Google Scholar 

  57. Harzstark AL, Ryan CJ (2008) Novel therapeutic strategies in development for prostate cancer. Expert Opin Investig Drugs 17(1):13–22

    Article  PubMed  CAS  Google Scholar 

  58. Carreca I, Balducci L (2009) Cancer chemotherapy in the older ­cancer patient. Oncology 27(6):633–642

    CAS  Google Scholar 

  59. Balducci L (2007) Molecular insights in cancer treatment and ­prevention. Int J Biochem Cell Biol 39(7–8):1329–1336

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Senior Adult Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Lodovico Balducci

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  1. Lodovico Balducci
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Correspondence to Lodovico Balducci .

Editor information

Editors and Affiliations

  1. School of Medicine, Department of Surgery, Yale University, New Haven, 06520, Connecticut, USA

    Ronnie Ann Rosenthal

  2. Downstate Medical Center, State University of New York, Clarkson Ave. 450, Brooklyn, 11203, New York, USA

    Michael E. Zenilman

  3. , Chairman, Department of Surgery, Sinai Hospital, 2401 West Belvedere Avenue, Baltimore, 21215, Maryland, USA

    Mark R. Katlic

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Balducci, L. (2011). Cancer, Carcinogenesis, and Aging. In: Rosenthal, R., Zenilman, M., Katlic, M. (eds) Principles and Practice of Geriatric Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6999-6_3

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  • DOI: https://doi.org/10.1007/978-1-4419-6999-6_3

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-6998-9

  • Online ISBN: 978-1-4419-6999-6

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