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Progress in Early Detection and Management of Oral Dysplasia: Components for a Multifaceted Progression Risk Model

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Abstract

A chief barrier to prevention of oral squamous cell carcinoma is our limited ability to differentiate oral premalignant lesions (OPLs) that are likely to progress to cancer from their more benign counterparts. This paper describes some of the newer technologies being used to capture novel information in OPLs of clinical, histological and molecular changes that are associated with progression risk. These approaches include: the use of tissue optics and molecular paints to improve lesion visualization; high resolution computer microscopy to detect subtle histological change; and genomics for tracking high-risk molecular clones across the oral mucosa and for gene-specific targeting of future drug therapies. The integration of information from these different approaches into multifaceted risk models can guide the evolution of new strategies for detecting and managing OPLs.

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Acknowledgements

Supported by grants from the National Institute of Dental and Craniofacial Research R01DE13124 and R01 DE17013R01DE13124.

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Authors and Affiliations

  1. Department of Cancer Control Research, British Columbia Cancer Agency Research Centre, University of British Columbia, Vancouver, BC, Canada

    Miriam P. Rosin

  2. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada

    Miriam P. Rosin

  3. BC Oral Cancer Prevention Program, British Columbia Cancer Agency Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada

    Miriam P. Rosin

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  1. Miriam P. Rosin
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  2. Catherine F. Poh
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  3. S. Y. Catherine Kang
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  4. Calum E. MacAulay
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  5. Lewei Zhang
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Correspondence to Miriam P. Rosin .

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  1. , MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Hills Road, Cambridge, CB20XZ, United Kingdom

    Rebecca C. Fitzgerald

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Rosin, M.P., Poh, C.F., Kang, S.Y.C., MacAulay, C.E., Zhang, L. (2011). Progress in Early Detection and Management of Oral Dysplasia: Components for a Multifaceted Progression Risk Model. In: Fitzgerald, R. (eds) Pre-Invasive Disease: Pathogenesis and Clinical Management. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6694-0_15

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