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Hereditary Colorectal Cancer pp 133–146Cite as

MUTYH-Associated Polyposis

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Part of the book series: M.D. Anderson Solid Tumor Oncology Series ((MDA,volume 5))

Abstract

MUTYH-associated polyposis (MAP) is an autosomal recessive disorder characterised by multiple colorectal adenomas and carcinoma. It is caused by inherited mutations in the human MutY homologue gene (MUTYH). MUTYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2’-deoxyguanosine, one of the most stable products of oxidative DNA damage. The failure to correct this mispair is thought to cause the characteristic signature of G:C to T:A mutations found in MAP-associated tumours.

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Acknowledgements

Professor Cheadle is supported by Cancer Research UK, Cancer Research Wales and the Wales Gene Park.

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Authors and Affiliations

  1. Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK

    Jeremy P. Cheadle

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  1. Jeremy P. Cheadle
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Correspondence to Jeremy P. Cheadle .

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Editors and Affiliations

  1. M.D. Anderson Cancer Center, Surgical Oncology, The University of Texas, Holcombe Blvd. 1515, Houston, 77030, Texas, USA

    Miguel A. Rodriguez-Bigas

  2. Associate Professor of Surgery, Brazilian Registry of Inherited, Colorec, University of São Paulo Medical School, Sao Paulo, Brazil

    Raul Cutait

  3. M.D. Anderson Cancer Center, Gastroenterology, The University of Texas, Houston, 77030, Texas, USA

    Patrick M. Lynch

  4. Cancer Research UK London Research Insti, Molecular and Population Genetics Labora, London, United Kingdom

    Ian Tomlinson

  5. Medical Center, Gastroenterology, Leiden University, Leiden, 2333 AA, Netherlands

    Hans F.A. Vasen

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Cheadle, J.P. (2010). MUTYH-Associated Polyposis. In: Rodriguez-Bigas, M., Cutait, R., Lynch, P., Tomlinson, I., Vasen, H. (eds) Hereditary Colorectal Cancer. M.D. Anderson Solid Tumor Oncology Series, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6603-2_7

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