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Hereditary Colorectal Cancer pp 67–85Cite as

DNA Mismatch Repair

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Part of the book series: M.D. Anderson Solid Tumor Oncology Series ((MDA,volume 5))

Abstract

The genome is subject to multiple forms of stress and damage that can lead to alterations in the integrity of DNA. The cell nucleus possesses several complex, integrated enzyme systems that identify altered DNA and repair it or, in the case of overwhelming damage, trigger cell death, which prevents the passage of a mutation to the next generation of cells. These systems are essential for the faithful replication of the genome, and germline defects in these systems give rise to familial cancer syndromes, each with a unique spectrum of neoplasia.

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Authors and Affiliations

  1. Gastroenterology, Baylor University Medical Center, 3500 Gaston Avenue (250 Hoblitzelle), Dallas, TX, 75246, USA

    C. Richard Boland

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  1. C. Richard Boland
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Correspondence to C. Richard Boland .

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Editors and Affiliations

  1. M.D. Anderson Cancer Center, Surgical Oncology, The University of Texas, Holcombe Blvd. 1515, Houston, 77030, Texas, USA

    Miguel A. Rodriguez-Bigas

  2. Associate Professor of Surgery, Brazilian Registry of Inherited, Colorec, University of São Paulo Medical School, Sao Paulo, Brazil

    Raul Cutait

  3. M.D. Anderson Cancer Center, Gastroenterology, The University of Texas, Houston, 77030, Texas, USA

    Patrick M. Lynch

  4. Cancer Research UK London Research Insti, Molecular and Population Genetics Labora, London, United Kingdom

    Ian Tomlinson

  5. Medical Center, Gastroenterology, Leiden University, Leiden, 2333 AA, Netherlands

    Hans F.A. Vasen

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Boland, C.R. (2010). DNA Mismatch Repair. In: Rodriguez-Bigas, M., Cutait, R., Lynch, P., Tomlinson, I., Vasen, H. (eds) Hereditary Colorectal Cancer. M.D. Anderson Solid Tumor Oncology Series, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6603-2_4

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  • DOI: https://doi.org/10.1007/978-1-4419-6603-2_4

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