Skip to main content

Liquid Breathing and Artificial Gills

  • Chapter
  • First Online:
Ocean Outpost

Abstract

Liquid breathing is a type of respiration in which a human breathes an oxygen-rich liquid such as a perjluorocarbon (PFC).1 PFCs were synthesized during the development of the atomic bomb (the Manhattan Project) when they were given the codename “Joe’s stuff”. PFCs are organic compounds in which all hydrogen atoms have been replaced by halogens, usually fluoride. In medical applications, the compounds are being evaluated as contrast agents for computerized tomography (CT) and magnetic resonance imaging (MRI), as sensitizing agents during radiotherapy, and as possible oxygen-carrying agents. Because PFCs are stable, inert compounds, they do not react with living tissues, which makes them an ideal candidate for all sorts of medical applications. Currently, the primary application of liquid breathing is the medical treatment of lung problems in babies born prematurely [1, 2].

“It will happen. Surgery will affix a set of artificial gills to man’s circulatory system – right here at the neck – which will permit him to breathe oxygen from the water like a fish. Then the lungs will be by-passed and he will be able to live and breathe in any depth for any amount of time without harm.”

Jacques-Yves Cousteau

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 37.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Davies, M.W.; Sargent, P.H. Partial Liquid Ventilation for the Prevention of Mortality and Morbidity in Paediatric Acute Lung Injury and Acute Respiratory Distress Syndrome. Cochrane Database of Systematic Reviews, CD003845 (2004).

    Google Scholar 

  2. Leach, C.L.; Greenspan, J.S.; Rubenstein, D. et al. Partial Liquid Ventilation with Perflubron in Premature Infants with Severe Respiratory Distress Syndrome. New England Journal of Medicine, 335, 761 (1996).

    Article  Google Scholar 

  3. Norris, M.K.; Fuhrman, B.P.; Leach, C.L. Liquid Ventilation: It’s Not Science Fiction Anymore. American Association of Critical-Care Nurses, Clinical Issues in Critical-Care Nursing, 5, 246 (1994).

    Google Scholar 

  4. Shaffer, T.H. A Brief Review: Liquid Ventilation. Undersea Biomedical Research, 14, 169 (1987).

    Google Scholar 

  5. Hirschl, R.B. Advances in the Management of Respiratory Failure: Liquid Ventilation in the Setting of Respiratory Failure. ASAIO Journal, 42, 209 (1996).

    Google Scholar 

  6. Hirschl, R.B.; Pranikoff, T.; Wise, C. et al. Initial Experience with Partial Liquid Ventilation in Adult Patients with the Acute Respiratory Distress Syndrome. Journal of the American Medical Association, 275, 383 (1996).

    Article  Google Scholar 

  7. Kacmarek, R.M.; Wiedemann, H.P.; Lavin, P.T. et al. Partial Liquid Ventilation in Adult Patients with Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine, 173, 882 (2006).

    Article  Google Scholar 

  8. Kirmse, M.; Fujino, Y.; Hess, D.; Kacmarek, R.M. Positive End-Expiratory Pressure Improves Gas Exchange and Pulmonary Mechanics during Partial Liquid Ventilation. American Journal of Respiratory and Critical Care Medicine, 158, 1550 (1998).

    Google Scholar 

  9. Reickert, C.; Pranikoff, T.; Overbeck, M. et al. The Pulmonary and Systemic Distribution and Elimination of Perflubron from Adult Patients Treated with Partial Liquid Ventilation. Chest, 119, 515 (2001).

    Article  Google Scholar 

  10. Shaffer, T.H.; Wolfson, M.R.; Clark, L.C., Jr. Liquid Ventilation. Pediatric Pulmonology, 14, 102 (1992).

    Article  Google Scholar 

  11. Kylstra, J.A.; Tissing, M.O.; van der Maen, A. Of Mice as Fish. Transactions, American Society for Artificial Internal Organs, 8, 378 (1962).

    Google Scholar 

  12. Clark, L.C., Jr; Gollan, F. Survival of Mammals Breathing Organic Liquids Equilibrated with Oxygen at Atmospheric Pressure. Science, 152, 1755 (1966).

    Article  Google Scholar 

  13. Cox, C.A.; Wolfson, M.R.; Shaffer, T.H. Liquid Ventilation: A Comprehensive Overview. Neonatal Network, 15, 31 (1996).

    Google Scholar 

  14. Hughes, G.M. How a Fish Extracts Oxygen from Water. New Scientist, 247, 346–348 (1961).

    Google Scholar 

  15. Hughes, G.M.; Morgan, M. The Structure of Fish Gills in Relation to their Respiratory Function. Biological Review, 48, 419–475 (1973).

    Article  Google Scholar 

  16. Bijtel, J.H. The Structure and the Mechanism of Movements of the Gill Filaments in Teleostei. Archives Néerlandaises de Zoologie, 8, 267–288 (1949).

    Article  Google Scholar 

  17. Eckert, R.; Randall, D.; Augustine, G. Exchange of Gas. In: R. Eckert, and D. Randall (eds), Animal Physiology Mechanism and Adaptations, 3rd edn, pp. 474–519. W.H. Freeman and Company, New York (1988).

    Google Scholar 

  18. Matsuda, N.; Sakai, K. Technical Evaluation of Oxygen Transfer Rates of Fish Gills and Artificial Gills. ASAIO Journal, 45, 293–298 (1999).

    Article  Google Scholar 

  19. Matsuda, N. Modeling of Gas Transfer in Biological and Artificial Membrane Modules and Acceleration of Gas Transfer Rate, PhD thesis of Waseda University (2001).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Seedhouse, E. (2011). Liquid Breathing and Artificial Gills. In: Ocean Outpost. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6357-4_9

Download citation

Publish with us

Policies and ethics