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Gene-Based Therapies for Cancer pp 95–111Cite as

Gene Therapy for Malignant Pleural Mesothelioma

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Part of the book series: Current Cancer Research ((CUCR))

Abstract

Malignant pleural mesothelioma (MPM) is a neoplasm of the intrathoracic cavity associated with asbestos exposure that presents with symptoms of dyspnea, a pleural effusion, and nonpleuritic chest pain. MPM is associated with a poor prognosis with current treatment regimens having only a modest effect on its progressive course. However, a number of preclinical and early clinical studies have been performed investigating novel gene therapy strategies that have the potential of positively impacting the disease course. These strategies include induction of apoptosis, angiogenesis blockade, suicide gene expression, immunogene therapy, and viral oncolysis.

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Authors and Affiliations

  1. Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Steven M. Albelda

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  1. Edmund K. Moon
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  2. Sunil Singhal
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  3. Andrew R. Haas
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  4. Daniel H. Sterman
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  5. Steven M. Albelda
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Correspondence to Steven M. Albelda .

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  1. M.D.Anderson Cancer Center, Dept. Thoracic & Cardiovascular Surgery, University of Texas, Holcombe Blvd. 1515, Houston, 77030, USA

    Jack A. Roth

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Moon, E.K., Singhal, S., Haas, A.R., Sterman, D.H., Albelda, S.M. (2010). Gene Therapy for Malignant Pleural Mesothelioma. In: Roth, J. (eds) Gene-Based Therapies for Cancer. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6102-0_7

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