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Epidemiology of Hepatocellular Carcinoma

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Molecular Genetics of Liver Neoplasia

Part of the book series: Cancer Genetics ((CANGENETICS))

Abstract

Hepatocellular carcinoma (HCC) is the sixth leading cause of cancer worldwide and the third leading cause of cancer-related deaths. Most HCC cases (<80%) are attributable to hepatitis B virus (HBV) or hepatitis C virus (HCV) infections, explaining the distinct geographic distribution of HCC with most cases found in developing countries with endemic infections. Strong and continuing recent increases in HCC rates have been observed in Western countries where from 15–50% of HCC cases are cryptogenic. Together with findings from recent epidemiologic research, this suggests the potential importance of additional non-viral or alcohol-related etiologic factors for HCC in these populations, including non-alcoholic steatohepatitis, obesity and Type 2 diabetes mellitus.

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Authors and Affiliations

  1. Section of Gastroenterology and Hepatology and Clinical Epidemiology and Outcomes Program in Health Service Research, Michael E DeBakey Veterans Affairs Medical Center and Bayler College of Medicine, 2002 Holcombe Blvd. (MS152), Houston, TX, 77030, USA

    Donna L. White Ph.D. & Hashem B. El-Serag (Chief)

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  1. Donna L. White Ph.D.
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  2. Hashem B. El-Serag
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Correspondence to Hashem B. El-Serag .

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Editors and Affiliations

  1. Lab. Human Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Xin Wei Wang

  2. Lab. Experimental Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Joe W. Grisham

  3. Lab. Experimental Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Snorri S. Thorgeirsson

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White, D.L., El-Serag, H.B. (2010). Epidemiology of Hepatocellular Carcinoma. In: Wang, X., Grisham, J., Thorgeirsson, S. (eds) Molecular Genetics of Liver Neoplasia. Cancer Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6082-5_4

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